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Transforming growth factor beta (TGF-beta) and the platelet-derived growth factor (PDGF) are potent mitogenic polypeptides which enhance rates of wound healing in experimental animals; in contrast, glucocorticoids inhibit wound repair. The potential of TGF-beta and PDGF to reverse this inhibition in healing was tested in methylprednisolone-treated rats with(More)
The effects of in vivo treatment with xenogeneic anti-idiotypic antibodies were examined in an anti-Ia idiotypic system. Monoclonal antibody 14-4-4S, specific for Ia.7, has been shown to bear idiotopes that are expressed at readily detectable levels in conventional alloantibody responses. Sera from mice treated with purified anti-idiotypic antibodies(More)
Platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-beta) markedly potentiate tissue repair in vivo. In the present experiments, both in vitro and in vivo responses to PDGF and TGF-beta were tested to identify mechanisms whereby these growth factors might each enhance the wound-healing response. Recombinant human PDGF B-chain(More)
The experiments reported here demonstrate that the event leading to CTL-induced nuclear disintegration is kinetically similar (t1/2 = 3.1 +/- 0.8 min) to that reported for CTL-induced plasma membrane disintegration as measured by 51Cr release. However, the expression of the lethal event by detergent-soluble 125I release occurs so rapidly that the time(More)
The pattern of progressive release of cytosolic (52Cr) and nuclear (125IUdR) labels from normal or tumor cells being lysed by CTL is strikingly different from the pattern observed when similar cells are lysed by Ab + C or hypotonic shock. We propose that these differences reflect physiologic differences in the lytic events associated with Ab + C- and(More)
This study represents a multicenter survey on the management of patients with Crigler-Najjar syndrome (CNS) type 1. The aim of the survey was to find guiding principles for physicians in the care of these patients. Fifty-seven patients were included. At the time of inclusion, 21 patients had received a liver transplant (37%). The average age at(More)
Platelet-derived growth factor (PDGF) and transforming growth factor-~ (TGF-/~) markedly poten-tiate tissue repair in vivo. In the present experiments, both in vitro and in vivo responses to PDGF and TGF-B were tested to identify mechanisms whereby these growth factors might each enhance the wound-healing response. Recombinant human PDGF B-chain homodimers(More)
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