Victoria Mary Stoll

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Purpose To test whether the increased signal-to-noise ratio of phosphorus 31 (31P) magnetic resonance (MR) spectroscopy at 7 T improves precision in cardiac metabolite quantification in patients with dilated cardiomyopathy (DCM) compared with that at 3 T. Materials and Methods Ethical approval was obtained, and participants provided written informe consent.(More)
Background Blood flow through the heart is a fundamental aspect of the function of the cardiovascular system. Left ventricular intra-cardiac flow, as assessed by retrospectively gated 4D flow, can be divided into 4 functional components; direct flow (DF), delayed ejection flow (DEF), retained inflow (RI) and residual volume (RV). Additionally the kinetic(More)
Background Despite the fact that stroke is a leading cause of disability, in up to 40% of cases no cause is found on routine clinical investigation. Although a patent foramen ovale (PFO) is an attractive mechanism to explain these cryptogenic strokes, using current imaging techniques, distinguishing between a causative rather than an incidental PFO remains(More)
Background Phosphorous magnetic resonance spectroscopy (PMRS) allows insight into cardiac energetics in vivo, but it is a technique with an intrinsically low signal to noise ratio (SNR). The 2.4x increased SNR, that is predicted by theory at 7T compared to 3T, should allow detection of smaller changes in metabolite concentrations or measurement of changes(More)
Background Bicuspid aortic valve disease (BAV) is associated with dilatation of the proximal aorta and abnormal flow patterns, particularly increased helical flow and changes in the aortic wall shear stress. These altered flow patterns may be partly responsible for the aortic dilation, though the aetiology is still unclear. Aortic valve replacement can(More)
AIMS Atrial flutter (AFl) and atrial fibrillation (AFib) share many clinical risk factors and potential mechanisms with atherosclerosis. Despite this, an association between stable coronary artery disease (CAD) and atrial arrhythmias has not previously been documented. To investigate this hypothesis we measured the incidence of occult coronary atheroma on(More)
Background Despite different aetiology of myocardial damage in dilated cardiomyopathy (DCM) and ischaemic cardiomyopathy (IHD), cardiac remodelling occurs in both, culminating in the end result of a dilated left ventricle with impaired function. Cardiac remodelling is a complex process in which numerous cellular, mechanical and flow processes become(More)
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