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Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
DNA replication and repair enzyme Flap Endonuclease 1 (FEN1) is vital for genome integrity, and FEN1 mutations arise in multiple cancers. FEN1 precisely cleaves single-stranded (ss) 5′-flaps oneExpand
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DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction*
Human flap endonuclease-1 (hFEN1) catalyzes the essential removal of single-stranded flaps arising at DNA junctions during replication and repair processes. hFEN1 biological function must beExpand
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Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay† †Electronic supplementary information (ESI) available: Experimental procedures and spectroscopic data. See DOI:
A new route to a tetracyclic lactam was developed and the product, called VG1, was found to inhibit nonsense-mediated mRNA decay at μM concentrations.
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A conserved loop–wedge motif moderates reaction site search and recognition by FEN1
Abstract DNA replication and repair frequently involve intermediate two-way junction structures with overhangs, or flaps, that must be promptly removed; a task performed by the essential enzyme flapExpand
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Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay†
A significant proportion of genetic diseases, as well as many cancers, are associated with a particular type of mutation which gives rise to a premature termination codon (PTC) before the genuineExpand
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Corrigendum: Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
Nature Communications 8 Article number: 15855 (2017); Published: 27 June 2017; Updated: 7 August 2017 The financial support for this Article was not fully acknowledged. The Acknowledgements shouldExpand