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Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
- S. Tsutakawa, M. Thompson, +14 authors J. Tainer
- Biology, Medicine
- Nature communications
- 27 June 2017
DNA replication and repair enzyme Flap Endonuclease 1 (FEN1) is vital for genome integrity, and FEN1 mutations arise in multiple cancers. FEN1 precisely cleaves single-stranded (ss) 5′-flaps one… Expand
DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction*
- Sana I. Algasaier, Jack C. Exell, +6 authors J. Grasby
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 16 February 2016
Human flap endonuclease-1 (hFEN1) catalyzes the essential removal of single-stranded flaps arising at DNA junctions during replication and repair processes. hFEN1 biological function must be… Expand
Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay† †Electronic supplementary information (ESI) available: Experimental procedures and spectroscopic data. See DOI:…
- Victoria J. B. Gotham, Melanie C. Hobbs, Ryan N Burgin, D. Turton, C. Smythe, I. Coldham
- Chemistry, Medicine
- Organic & biomolecular chemistry
- 7 January 2016
A new route to a tetracyclic lactam was developed and the product, called VG1, was found to inhibit nonsense-mediated mRNA decay at μM concentrations.
A conserved loop–wedge motif moderates reaction site search and recognition by FEN1
- M. Thompson, Victoria J. B. Gotham, Barbara Ciani, J. Grasby
- Biology, Medicine
- Nucleic acids research
- 7 June 2018
Abstract DNA replication and repair frequently involve intermediate two-way junction structures with overhangs, or flaps, that must be promptly removed; a task performed by the essential enzyme flap… Expand
Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay†
A significant proportion of genetic diseases, as well as many cancers, are associated with a particular type of mutation which gives rise to a premature termination codon (PTC) before the genuine… Expand
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Corrigendum: Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
- S. Tsutakawa, M. Thompson, +14 authors J. Tainer
- Biology, Medicine
- Nature Communications
- 7 August 2017
Nature Communications 8 Article number: 15855 (2017); Published: 27 June 2017; Updated: 7 August 2017 The financial support for this Article was not fully acknowledged. The Acknowledgements should… Expand