Victoria J Simpson

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Long- and Short-Sleep (LS and SS) mice were selectively bred for differences in ethanol-induced loss of the righting reflex (LORR) and have been found to differ in LORR induced by various anesthetic agents. We used a two-stage mapping strategy to identify quantitative trait loci (QTLs) affecting duration of LORR caused by the general anesthetic etomidate(More)
  • V J Simpson, T E Johnson, R F Hammen
  • 1986
DNA, isolated from age-synchronous senescent populations of Caenorhabditis elegans has been quantitatively and qualitatively analyzed for the presence of 5-methylcytosine. High performance liquid chromatography on two wild-type and several mutant strains of C. elegans failed to detect any 5-methylcytosine. The restriction endonuclease isoschizomers, HpaII(More)
Short-Sleep (SS) and Long-Sleep (LS) mice differ in initial sensitivity to ethanol. Ethanol acts as an antagonist at N-methyl D-aspartate receptors (NMDARs). Therefore, we tested whether SS and LS mice also differ in initial sensitivity to NMDAR antagonists. Systemic injection (intraperitoneal) of either the noncompetitive NMDAR antagonist MK-801(More)
We report differential central nervous system (CNS) sensitivity to propofol between Long Sleep (LS) and Short Sleep (SS) mice, selectively bred for their differential CNS sensitivity to ethanol. Intravenous propofol requirements for loss of righting reflex, or sleep time, were measured to define the extent of this sensitivity. LS mice slept approximately(More)
This chapter reviews the use of genetic models in the study of anesthetic drug action. Genetic model systems provide a novel approach to understanding mechanisms of anesthetic drug action. Many models have been derived using selection processes that emphasize differential drug sensitivity, producing animal lines that differ in their CNS drug response.(More)
FUNDING: Overall, 2004-2005 was another excellent year in which the department continued to excel in education, research and service. Research funding in the department was $4,501,221 (total costs) in NIH support (source: NIH Website). This is a decline of about 2 million from the previous year. While this decline is large and concerning, a major(More)
  • Contributing Authors, K Acevedo-Whitehouse, +16 authors A Fernández
  • 2009
(Funded under a variation to contract number CR0364) Executive summary Cetacean mass stranding events (MSEs) have puzzled humans for centuries. On the morning of 9 June 2008 common dolphins (Delphinus delphis) were found, some swimming, some stranded and some dead, in and around a small tidal tributary (Porth Creek, Percuil River) of the Fal Estuary in(More)
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