Victoria J. Davey

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BACKGROUND The optimal community-level approach to control pandemic influenza is unknown. METHODS We estimated the health outcomes and costs of combinations of 4 social distancing strategies and 2 antiviral medication strategies to mitigate an influenza pandemic for a demographically typical US community. We used a social network, agent-based model to(More)
BACKGROUND The US government proposes pandemic influenza mitigation guidance that includes isolation and antiviral treatment of ill persons, voluntary household member quarantine and antiviral prophylaxis, social distancing of individuals, school closure, reduction of contacts at work, and prioritized vaccination. Is this the best strategy combination? Is(More)
Using a networked, agent-based computational model of a stylized community, we evaluated thresholds for rescinding 2 community mitigation strategies after an influenza pandemic. We ended child sequestering or all-community sequestering when illness incidence waned to thresholds of 0, 1, 2, or 3 cases in 7 days in 2 levels of pandemic severity. An(More)
21 patients with AIDS and Kaposi's sarcoma were enrolled in an open therapeutic trial to determine the in vivo anti-retroviral activity of recombinant interferon-alpha (IFN-alpha). 8 (38%) showed a complete or partial anti-tumour response. The mean pretreatment CD4 count for the responders was 399 cells/microliter vs 154 cells/microliter for the(More)
OBJECTIVE To determine whether improper high-level disinfection practices during endoscopy procedures resulted in bloodborne viral infection transmission. DESIGN  Retrospective cohort study. SETTING  Four Veterans Affairs medical centers (VAMCs). PATIENTS  Veterans who underwent colonoscopy and laryngoscopy (ear, nose, and throat [ENT]) procedures(More)
Bacteriophage phiX174 immunization was used to measure CD4(+) T cell function in vivo in human immunodeficiency virus (HIV)-infected patients across all disease stages. Function was evaluated by measuring the ability of T cells to provide help to B cells in antibody production, amplification, and isotype switching. A total of 33 patients and 10 controls(More)
OBJECTIVES We measured HIV testing and seropositivity among veterans in Veterans Affairs (VA) care for calendar years 2009 through 2011 and analyzed 2011 results by patient demographics. METHODS We performed a repeated-measures cross-sectional study using standardized electronic data extraction from the VA electronic health records for all veterans with(More)
STUDY OBJECTIVE To evaluate the toxicity and clinical efficacy of interferon-alpha 2b (IFN-alpha) in patients with asymptomatic human immunodeficiency virus (HIV) infection. DESIGN Randomized, placebo-controlled, and double-blind study. SETTING Outpatient clinic of a government referral-based research hospital. PATIENTS Volunteer sample of 34 patients(More)
Previously published isolation techniques with T cell blasts and monocyte-derived macrophages (MDM) were used to recover HIV from the PBMC of a group of 23 asymptomatic seropositive individuals. Viral isolation was more readily accomplished by MDM coculture resulting in 9 isolates being obtained exclusively by this method (macrophage tropic strains). To(More)
To evaluate acceptance of the emergency department as a setting for vaccine delivery, we interviewed and offered pneumococcal vaccine to 338 high-risk ED patients presenting with unrelated complaints. Only 27 (8%) had previously been immunized with pneumococcal vaccine. Of the unimmunized, 187 (60%) initially indicated that they would accept vaccine during(More)