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Under uncertainty, the brain uses previous knowledge to transform sensory inputs into the percepts on which decisions are based. When the uncertainty lies in the timing of sensory evidence, however, the mechanism underlying the use of previously acquired temporal information remains unknown. We study this issue in monkeys performing a detection task with… (More)
A new exploration of the cortical network underlying our language abilities by Hauk et al., in this issue of Neuron, shows that the process of giving meaning to words differentially activates the motor cortex according to the semantic category of the word.
BACKGROUND The relationship between the complexity of the hypervariable region 1 quasispecies of HCV and responsiveness to therapy is not completely clear. OBJECTIVE To investigate the importance of quasispecies as a predictive factor of rapid (RVR), early (EVR) and sustained (SVR) virologic response. METHODS Prospective analysis of 82 patients with… (More)
Sensory perception has traditionally been attributed to the activation of sensory cortices. However, by inducing an illusory perception of movement, Naito and colleagues show in this issue of Neuron that the illusory perception of movement is related to activation of primary motor cortex.
Decisions emerge from the concerted activity of neuronal populations distributed across brain circuits. However, the analytical tools best suited to decode decision signals from neuronal populations remain unknown. Here we show that knowledge of correlated variability between pairs of cortical neurons allows perfect decoding of decisions from population… (More)
In a placebo-controlled, double-blind, crossover study with a washout phase of 2 months between each treatment period, single daily doses of 10 and 30 mg of astemizole were given to 12 patients with extrinsic asthma during 28 consecutive days. Albuterol was allowed as concurrent medication when needed. On days 0, 7, and 28 specific bronchial provocation… (More)
We thank Y. Li and K. Krishnamurthy for their insightful comments on our study, as well as their synthesis of the extensive supporting literature. We wish to clarify our perspective on the broad hypothesis that Li and Krishnamurthy emphasize, concerning a general role that LIP might play in perceptual decision-making. We do not believe that our study… (More)
Visual illusions are sensory percepts that can't be explained completely from the observed image but that arise from the internal workings of the visual system. In them, we perceive something that is not physically present in the image, and are of interest to neuroscientists because they reveal visual processing that we are not normally aware of. For… (More)
17 We routinely identify objects with our hands, and the physical attributes of touched objects are often 18 held in short-term memory to aid future decisions. However, the brain structures that selectively 19 process tactile information to encode object shape are not fully identified. Here we describe the areas 20 within the human cerebral cortex that… (More)
In this issue of Neuron, Fetsch et al. (2014) show that microstimulation of motion-sensitive neurons in the visual cortex (MT/MST) of primates mimics the addition of sensory information for which the stimulated neurons are selective. Such microstimulation increases the confidence that monkeys have in their decisions about motion direction.