Victor Yakimov

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Antisense oligonucleotides that recruit RNase H and thereby cleave complementary messenger RNAs are being developed as therapeutics. Dose-dependent hepatic changes associated with hepatocyte necrosis and increases in serum alanine-aminotransferase levels have been observed after treatment with certain oligonucleotides. Although general mechanisms for(More)
BACKGROUND Inuit have lived for thousands of years in an extremely cold environment on a diet dominated by marine-derived fat. To investigate how this selective pressure has affected the genetic regulation of fatty acid metabolism, we assessed 233 serum metabolic phenotypes in a population-based sample of 1570 Greenlanders. METHODS AND RESULTS Using(More)
INTRODUCTION Infusion of glyceryl trinitrate (GTN), a donor of nitric oxide, induces immediate headache in humans that in migraineurs is followed by a delayed migraine attack. In order to achieve increased knowledge of mechanisms activated during GTN-infusion this present study aims to investigate transcriptional responses to GTN-infusion in the rat(More)
In order to ensure safe charging of inflammable liquids and gases, the technological equipment must be preliminarily purged with nitrogen to complete removal of the air. At the same time, the purging system must ensure a minimum consumption of the inert gas. However, in practice the consumption of nitrogen is frequently not monitored and the equipment is(More)
Toxic gases and liquids capable of producing acute injurious effects are rather often used as raw materials for the chemical synthesis of drugs. These toxic gases and liquids are listed in state safety standard GOST 12.1.005-88 [I], as they are able to cause acute damage to mucous membranes of the respiratory tract and eyes. The industrial plant area, where(More)
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