Victor T. Miller

Learn More
Ischemic strokes occurring in patients with nonrheumatic atrial fibrillation are due to a variety of mechanisms, not exclusively to cardiogenic embolism. Without knowledge of antithrombotic therapy assignment, we categorized strokes in the Stroke Prevention in Atrial Fibrillation Study as presumed cardioembolic or noncardioembolic. We then compared patient(More)
P rogressive neurological deterioration in patients with recent stroke or transient ischemic attack (TIA) is a distressing and all too common occurrence. Anticoagulation is an important therapeutic consideration for many of these patients. The use of heparin in patients with acute brain ischemia will be reviewed in this paper. Anticoagulation with heparin(More)
Lacunae are small, deep cerebral infarcts known to occur in hypertensive patients. Although frequently asymptomatic, they sometimes produce characteristic clinical syndromes. Postmortem studies have implicated small-vessel disease in their pathogenesis, and, as a result, conservative management has been advocated. Computed tomography (CT) has provided new(More)
The Stroke Prevention in Atrial Fibrillation II study compared the efficacy and safety of aspirin and warfarin in patients with atrial fibrillation. Three neurologists, blinded to patient therapy, categorized the pathophysiology of ischemic strokes that occurred in the trial based on predetermined clinical criteria. Upon analyzing the patients being treated(More)
The importance of efficiently representing each abstract level of a complex model has become significant for many reasons. Because of the size of complex models, an organizational methodology is needed as an aid during both development and investigation of a system. In addition, some modeling formalisms are design to deseribe certain classes of systems(More)
We gave prostacyclin infusions to seven patients with acute cerebral infarction. Patients without CT evidence of infarction improved, but those who already had hypodensities on CT did not benefit. Increased platelet activity, measured by plasma beta-thromboglobulin, decreased significantly (p less than 0.01) during prostacyclin administration to normal(More)
Response In their letter, Bladin and Burns repeat previously published arguments, 1 without considering the particulars of our study. 2 They have cited us incorrectly several times, suggesting that they did not read our paper accurately: 1. "An absolute precision of ±0.1 mm. .. was. .. assumed by the authors." In fact, we stated that "the calipers could be(More)