Victor Stepanenko

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Experiments were made on randombred male mice weighing 18-20 g maintained on the light regimen L:D-12:12. The animals were given a single injection i. p. of a hypotetraploid subline of Ehrlich's ascites tumor. Fluctuations in the number of mitotic cells and no changes in the number of DNA-synthesizing cells were established. This indicates that(More)
Experiments on white random-bred male mice were made to study the effect of L-thyroxine on cell proliferation of the hypotetraploid strain of Ehrlich's ascites carcinoma. It was shown that prolonged thyroxine administration (during 6 days of carcinoma growth) lead to synchronization of cell proliferation and the maximum values of the mitotic index was found(More)
The concept of autonomy of tumors in the body is currently under critical appraisal. It has been shown that factors regulating cell division in normal tissues also act on tumor tissue [1-3, 4-6]. However, there is insufficient evidence of this kind at present for definite conclusions to be drawn on the mechanisms regulating cell division in tumors.(More)
A p r e v i o u s study of a hyperd ip lo td s t ra in of E h r l i c h ' s a s e i t e s tumor (EAT) on the 5th-gth day of i ts growth with 12 h of dayl ight and 12 h of d a r k n e s s showed that this tumor t i s sue is c h a r a c t e r i z e d by a d i s t inc t rhythm of the number of dividing ce l l s , but by absence of rhythm of the number of(More)
Experiments on white random-bred male mice were made to study the effect of L-thyroxine on cell proliferation of the hyperdiploid strain of Ehrlich's ascites carcinoma. It was shown that upon prolonged thyroxine administration (during 6 days of carcinoma growth) the action of the latter appeared dose-dependent. The doses used were 1, 10, 30, 60, 100(More)