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Skeletal muscle atrophy is a common feature in alcoholism that affects up to two-thirds of alcohol misusers, and women appear to be particularly susceptible. There is also some evidence to suggest that malnutrition exacerbates the effects of alcohol on muscle. However, the mechanisms responsible for the myopathy remain elusive, and some studies suggest that(More)
Polyphenols contained within plant tissues are consumed in significant amounts in the human diet and are known to influence a number of biological processes. This study investigated the effects of an anthocyanin-rich berry-extract on glucose uptake by human intestinal Caco-2 cells. Acute exposure (15 min) to berry extract (0.125%, w/v) significantly(More)
Liquid enteral formulas are commonly used as a sole source of nutritional support of patients in hospital and community settings. Their effect on appetite has important consequences for dietary management of such patients and is likely to be affected by the formula composition. The aim of the present study was to compare appetite within healthy subjects(More)
Wound healing in muscle involves the deposition of collagen, but it is not known whether this is achieved by changes in the synthesis or the degradation of collagen. We have used a reliable flooding dose method to measure collagen synthesis rate in vivo in rat abdominal muscle following a surgical incision. Collagen synthesis rate was increased by 480% and(More)
China is encountering formidable healthcare challenges brought about by the problem of aging. By 2050, there will be 400 million Chinese citizens aged 65+, 150 million of whom will be 80+. The undesirable consequences of the one-child policy, rural-to-urban migration, and expansion of the population of 'empty nest' elders are eroding the traditional family(More)
AIMS Previous immunohistochemical studies have shown that the post-translational formation of aldehyde-protein adducts may be an important process in the aetiology of alcohol-induced muscle disease. However, other studies have shown that in a variety of tissues, alcohol induces the formation of various other adduct species, including hybrid(More)
BACKGROUND The pathogenesis of diarrhea in patients receiving enteral feeding includes colonic water secretion, antibiotic prescription, and enteropathogenic colonization, each of which involves an interaction with the gastrointestinal microbiota. OBJECTIVE The objective was to investigate temporal changes in the concentrations of fecal microbiota and(More)
OBJECTIVES To examine the prevalence of hazardous drinking among staff in a UK university and its association with key socio-demographic features. DESIGN A cross-sectional study. SETTING A university in the UK. PARTICIPANTS All employees on the university employee database were eligible to participate. Those who completed and returned the(More)
(2016). Oxytocin inhibits ethanol consumption and ethanol induced dopamine release in the nucleus accumbens. Addiction Biology, In press. <a href=" (2014). Active coping toward predatory stress is associated with lower corticosterone and progesterone plasma levels and decreased methylation in the medial amygdala vasopressin system. the selective oxytocin(More)
(2016). Capacity building in physical activity and non-communicable disease prevention: a low-cost online training course can reach isolated practitioners [Forthcoming]. (2015). Chronic erythropoietin treatment improves diet-induced glucose intolerance in rats. Erythropoietin enhances whole body lipid oxidation during prolonged exercise in humans.(More)