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BACKGROUND High parity has long been suspected of being associated with an increased risk of cervical cancer, but previous analyses of this association have not taken the strong effect of human papillomavirus (HPV) into account. To assess the role of reproductive factors in the progression from HPV infection to cancer, we did a pooled analysis including(More)
The Internet has opened new avenues for information ac-cessing and sharing in a variety of media formats. Such popularity has resulted in an increase of the amount of resources consumed in backbone links, whose capacities have witnessed numerous upgrades to cope with the ever-increasing demand for bandwidth. Consequently, network traffic processing at(More)
Colorectal cancer is the second leading cause of cancer death in developed countries. Genome-wide association studies (GWAS) have successfully identified novel susceptibility loci for colorectal cancer. To follow up on these findings, and try to identify novel colorectal cancer susceptibility loci, we present results for GWAS of colorectal cancer (2,906(More)
BACKGROUND Use of oral contraceptives could increase risk of cervical cancer; however the effect of human papillomavirus (HPV), the main cause of cervical cancer, is not usually taken into account. We aimed to assess how use of oral contraceptives affected risk of cervical cancer in women who tested positive for HPV DNA. METHODS We pooled data from eight(More)
OBJECTIVE To develop gene expression profiles that characterise KRAS-, BRAF- or PIK3CA-activated- tumours, and to explore whether these profiles might be helpful in predicting the response to the epidermal growth factor receptor (EGFR) pathway inhibitors better than mutation status alone. DESIGN Fresh frozen tumour samples from 381 colorectal cancer (CRC)(More)
Congenital heart disease (CHD) is the most common birth abnormality and the etiology is unknown in the overwhelming majority of cases. ISLET1 (ISL1) is a transcription factor that marks cardiac progenitor cells and generates diverse multipotent cardiovascular cell lineages. The fundamental role of ISL1 in cardiac morphogenesis makes this an exceptional(More)
INTRODUCTION The traditional staging system is inadequate to identify those patients with stage II colorectal cancer (CRC) at high risk of recurrence or with stage III CRC at low risk. A number of gene expression signatures to predict CRC prognosis have been proposed, but none is routinely used in the clinic. The aim of this work was to assess the(More)
In most colorectal cancer (CRC) patients, outcome cannot be predicted because tumors with similar clinicopathological features can have differences in disease progression and treatment response. Therefore, a better understanding of the CRC biology is required to identify those patients who will benefit from chemotherapy and to find a more tailored therapy(More)
OBJECTIVE Exact tests for Hardy-Weinberg equilibrium are widely used in genetic association studies. We evaluate the mid p-value, unknown in the genetics literature, as an alternative for the standard p-value in the exact test. METHOD The type 1 error rate and the power of the exact test are calculated for different sample sizes, significance levels,(More)
—Novel packet I/O engines allow capturing traffic at multi-10Gb/s using only-software and commodity-hardware systems. This is achieved thanks to the application of techniques such as batch processing. Nevertheless, this feature involves degradation in the timestamp accuracy, which may be relevant for monitoring purposes. We propose two different approaches(More)