• Publications
  • Influence
A novel gammaretroviral shuttle vector insertional mutagenesis screen identifies SHARPIN as a breast cancer metastasis gene and prognostic biomarker
Breast cancer (BC) is the second leading cause of malignancy among U.S. women. Metastasis results in a poor prognosis and increased mortality, but the molecular mechanisms by which metastatic tumorsExpand
  • 17
  • 2
  • Open Access
A novel approach to identify driver genes involved in androgen-independent prostate cancer
BackgroundInsertional mutagenesis screens have been used with great success to identify oncogenes and tumor suppressor genes. Typically, these screens use gammaretroviruses (γRV) or transposons asExpand
  • 33
  • 1
  • Open Access
Replication-incompetent gammaretroviral and lentiviral vector-based insertional mutagenesis screens identify prostate cancer progression genes
Replication-incompetent gammaretroviral (γRV) and lentiviral (LV) vectors have both been used in insertional mutagenesis screens to identify cancer drivers. In this approach the vectors stablyExpand
  • 5
  • 1
  • Open Access
Identifying Cancer Driver Genes Using Replication-Incompetent Retroviral Vectors
Identifying novel genes that drive tumor metastasis and drug resistance has significant potential to improve patient outcomes. High-throughput sequencing approaches have identified cancer genes, butExpand
  • 3
  • Open Access
A novel retroviral mutagenesis screen identifies prognostic genes in RUNX1 mediated myeloid leukemogenesis
Using a novel retroviral shuttle vector approach we identified genes that collaborate with a patient derived RUNX1 (AML1) mutant. RUNX1 mutations occurs in 40% of myelodysplastic syndromes (MDS). MDSExpand
  • 3
  • Open Access
230. A Novel Gammaretroviral Shuttle Vector Insertional Mutagenesis Screen To Identify Breast Cancer Metastasis Genes
Retroviral insertional mutagenesis screens have been used to efficiently identify genes involved in a wide variety of cancers. Identifying causal driver genes in malignant disease is crucial toExpand