Victor M Klimenko

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Impairments to cognitive functions in in children and adults often result from various pathologies occurring during the prenatal period and early postnatal period of development (birth traumas, hypoxia, infectious diseases). The present study identified impaired learning in a Morris water maze in adult rats given interleukin-1β during the third week of(More)
Reactions of the brain to systemic LPS or IL-1 beta treatment were shown to have different thresholds, be mediated by different neurotransmitter systems, and have different mechanisms of realisation. Changes in behaviour and neurotransmitter systems activity of the hypothalamus induced by a systemic IL-1 beta treatment were shown to be mediated by its(More)
Impairments to cognitive functions in children and adolescents often result from a variety of types of prenatal pathology (birth traumas, ischemia, hypoxia, and allergic and infectious diseases in early life) accompanied by high levels of production of the proinflammatory cytokine interleukin-1β. The studies reported here identified impairments to the(More)
Administration of Interleukin-1 beta (IL-1 beta) in pyrogenic and subpyrogenic doses induced a depression of social and exploratory behaviour in rats. A reduction in locomotor activity only occurred with pyrogenic doses of the IL-1 beta. The low dose induced the reduction whereas the high dose the increase of anxiety in elevated plus maze. The opposite(More)
A number of studies showed association of mental status with heart rate variability. This work discovered a feature of frequency structure of heart rate variability that is associated with mental readiness. In three independent groups of 64, 39, and 19 volunteers by the factor analysis of heart rate periodograms, it has been discovered that there are at(More)
Studies were performed to investigate impairments to the formation of behavior arising as a result of increases in the proinflammatory cytokine interleukin-1beta in early postnatal ontogenesis. The cytokine was given at pyrogenic or subpyrogenic doses for one week (the first, second, or third week of life). Behavior was assessed at prepubertal age and in(More)
Hypotheses relating to the developmental nature of cognitive impairments in schizophrenia and other neuropathologies propose that the development of stable cognitive deficit involves important roles for hypoxia, trauma, and infections operating during the prenatal and early postnatal periods. These pathological states are accompanied by increases in the(More)
Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and(More)