Victor M Klimenko

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Administration of Interleukin-1 beta (IL-1 beta) in pyrogenic and subpyrogenic doses induced a depression of social and exploratory behaviour in rats. A reduction in locomotor activity only occurred with pyrogenic doses of the IL-1 beta. The low dose induced the reduction whereas the high dose the increase of anxiety in elevated plus maze. The opposite(More)
We performed comparative analyses of the genotype distribution and allelic frequencies of the rs948854 polymorphism (G/A) in the galanin gene's promoter in patients with multiple sclerosis (MS) and in healthy matched controls. In total 111 patients and 115 control subjects were included. The analyses revealed that the presence of the minor allele (G)(More)
The nervous mechanisms of regulation of the food intake are among the most important functions of the brain. Their investigation provided Pavlov with the basis for his work on the theory of conditioned reflexes. The concept of motivation also was derived from analysis of the activity of the food center. The fruitfulness of the study of nervous control of(More)
In preparation for a possible large epidemiological study of radiation-related leukemia in Chernobyl clean-up workers of Ukraine, histologic evaluation of 62 cases of leukemia and related disorders was conducted by a panel of expert hematologists and hematopathologists from the United States, France, and Ukraine. All cases were randomly selected from a(More)
Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and(More)
A number of studies showed association of mental status with heart rate variability. This work discovered a feature of frequency structure of heart rate variability that is associated with mental readiness. In three independent groups of 64, 39, and 19 volunteers by the factor analysis of heart rate periodograms, it has been discovered that there are at(More)
The proinflammatory cytokine tumor necrosis factor α (TNFα) is one of the main mediators of neuroimmune interactions. Increased production of TNFα in nerve and immune system cells occurs in infectious diseases, traumas, ischemia, and hypoxia. The present study addressed the role of TNFα in the formation of behavior during early postnatal ontogenesis. TNFα(More)
The Ca2+-dependent calpain system of intracellular proteases is involved in regulating a multitude of physiological body functions. However, hyperactivation of calpains in cells is observed during the development of a number of responses, and this leads to impairment to the functioning of vitally important physiological systems. We report here our use of a(More)
Impairments to cognitive functions in in children and adults often result from various pathologies occurring during the prenatal period and early postnatal period of development (birth traumas, hypoxia, infectious diseases). The present study identified impaired learning in a Morris water maze in adult rats given interleukin-1β during the third week of(More)
Impairments to cognitive functions in children and adolescents often result from a variety of types of prenatal pathology (birth traumas, ischemia, hypoxia, and allergic and infectious diseases in early life) accompanied by high levels of production of the proinflammatory cytokine interleukin-1β. The studies reported here identified impairments to the(More)