Victor I Filippov

  • Citations Per Year
Learn More
Introduction The state-of-the-art in the synthesis of superparamagnetic polyfunctional magnetically guided preparations (PMPs) for the diagnostics and treatment of various disorders is characterized by significant advantages in both experimental and clinical investigations [1 – 126]. Depending on the conditions (in vitro or in vivo, systemic or local),(More)
The method of magnetic neutron capture therapy (MNTC) of cancer can be described as a combination of two methods: the targeted delivery of drugs using magnetic carriers and the proper neutron capture therapy which consists in tumor irradiation with thermal neutrons following the delivery of 10B compounds to the tumor site. Two-component ultradispersed(More)
It has been demonstrated in cats that magnet-susceptible microspheres and liposomes containing neuromuscular blocking agents (dipyronium, pyrocurinum and diadonium) caused a deeper inhibition of the neuromuscular transmission in the limb placed in the magnetic field than in the control limb located beyond the field. The microparticles containing a(More)
PURPOSE The method of magnetic neutron capture therapy can be described as a combination of two methods: magnetic localization of drugs using magnetically targeted carriers and neutron capture therapy itself. METHODS AND MATERIALS In this work, we produced and tested two types of particles for such therapy. Composite ultradispersed ferro-carbon (Fe-C) and(More)
The effect of tubocurarine enclosed in phosphatidylcholine and cholesterol liposomes on EEG of cats and rats was studied. Five to 15 minutes after its intravenous administration EEGs showed polyspike complexes as well as "peak-wave" complexes. Similar EEG changes were recorded on intracerebroventricular injection of tubocurarine solution. The absence of EEG(More)
The experiments on cats have shown that liposomes containing ferrocolloid and neuromuscular blocking agents (diadonium or dipyronium) cause selective muscle relaxation in the animal limb placed into the magnetic field, compared to the control limb kept outside the field. This effect was not related to the action of the magnetic field per se on neuromuscular(More)