Victor Hugo Casanova Alcalde

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Although deficient CD8(+) T cell responses have long been associated with chronic viral infections, the underlying mechanisms are still unclear. Here we report that sustained transforming growth factor-beta (TGF-beta) expression and phosphorylation of its signaling mediator, Smad-2, were distinctive features of virus-specific CD8(+) T cells during chronic(More)
A key event in the pathogenesis of Alzheimer's disease (AD) is the accumulation of amyloid-β (Aβ) species in the brain, derived from the sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. Based on a systems biology study to repurpose drugs for AD, we explore the effect of lansoprazole, and other proton-pump inhibitors (PPIs),(More)
A full description of the ontogeny of the beta cell would guide efforts to generate beta cells from embryonic stem cells (ESCs). The first step requires an understanding of definitive endoderm: the genes and signals responsible for its specification, proliferation, and patterning. This report describes a global marker of definitive endoderm, Claudin-6(More)
This paper describes the development and application of an algorithm for object visual tracking from a sequence of images. The algorithm is based on window-matching techniques using the sum of squared differences (SSD) as a distance-similarity measure, but adding stochastic filtering. The algorithm is then applied for tracking: a vehicle on an urban(More)
Edgetic perturbations provide a plausible explanation for some complex phenomena connecting, for instance, mutations related to the same phenotype found on different genes (locus heterogeneity) when they affect the same interaction interface1,3. They can also explain how mutations on the same gene might cause different phenotypes (pleiotropy) by perturbing(More)
Despite the remarkable progress achieved in the identification of specific genes involved in breast cancer (BC), our understanding of their complex functioning is still limited. In this manuscript, we systematically explore the existence of direct physical interactions between the products of BC core and associated genes. Our aim is to generate a protein(More)
A key element to delineate the biology of individual tumors is the regulation of apoptosis. In this work, we functionally characterize two breast cancer associated genes, the proteasome 26S subunit ATPase 3 interacting protein (PSMC3IP) and the epithelial-stromal interaction 1 (EPSTI1), to explore their potential apoptotic role in breast cancer. We first(More)
Nowadays, due to the involved complex issues, teaching robotics is demanding new methodologies. One of the complex issues regarding robotics is the use of computer vision for a proper robot guiding control. At the University of Brasilia an educational robotic workstation around a Rhino XR4 robot was built. Students can perform experiences on kinematics,(More)
Combinatorial therapeutic approaches are an imperative to improve cancer treatment, because it is critical to impede compensatory signaling mechanisms that can engender drug resistance to individual targeted drugs. Currently approved drug combinations result largely from empirical clinical experience and cover only a small fraction of a vast therapeutic(More)