Victor H. Díaz Ramírez

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Piceatannol is a stilbene phytochemical from the seeds of Euphorbia lagascae, previously identified as an antileukemic principle. Piceatannol is considered an inhibitor of several tyrosine kinases. We recently reported that resveratrol, another stilbene phytoalexin from grape seeds, was an inhibitor of ATP synthase. Here, we demonstrated that piceatannol(More)
Mitochondrial proton F0F1-ATPase/ATP synthase synthesizes ATP during oxidative phosphorylation. In this study, we examined the effects of several groups of polyphenolic phytochemicals on the activity of the enzyme. Resveratrol, a stilbene phytoalexin that is present in grapes and red wine, concentration-dependently inhibited the enzymatic activity of both(More)
Sex and estrous cycle-related differences in the amphetamine (AMT)-stimulated release (pg/mg/min) of catecholamines (CA) from rat striatal and mediobasal hypothalamus (MBH) fragments were measured in an in vitro perifusion system. In striatal tissue from intact males, AMT stimulated the release of both norepinephrine (NE) and dopamine (DA). The(More)
Sex differences are described in both a lateralized behavior (amphetamine-elicited rotation) and in the lateralization of striatal dopamine (DA) content. Amphetamine (AMPH) elicited significantly more partial turns, total rotations and lateralized (net) rotations in female, than in male rats. The two sexes also differed in their pattern of net rotations(More)
In the present experiment we examined the effect of a direct in vitro infusion of progesterone upon spontaneous and amphetamine-stimulated in vitro dopamine (DA) release and post-superfusion DA tissue concentration of corpus striatum tissue fragments from ovariectomized and estrogen-treated female rats. An intermittent infusion of progesterone at a dose of(More)
A continuous flow perifusion system was used to measure the in vitro release rate, and percent release of endogenous norepinephrine (NE) and dopamine (DA) from rat brain fragments. Catecholamines (CA) were measured simultaneously in effluent fractions and in tissue fragments following perifusion using a modified radioenzymatic assay. Employing this(More)
In the present experiment we examined the temporal effects of progesterone (P) upon in vitro dopamine (DA) release from superfused corpus striatum (CS) and medial basal hypothalami (MBH) tissue fragments. In ovariectomized-estrogen-primed adult female rats, P was systemically administered at 0.5, 2, 4, 12 or 24 h prior to sacrifice for CS and at 4 or 24 h(More)
Our earlier studies have identified oligomycin sensitivity-conferring protein (OSCP), a subunit of proton F0F1-ATPase/ATP synthase in the mitochondrial inner membranes, as a new estradiol binding protein. This finding suggests that mitochondrial ATPase/ATP synthase could be a potential target for estradiol or compounds with similar structures. Here, we(More)