Victor Ferrari

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WRITING COMMITTEE MEMBERS Vallerie V. McLaughlin, MD, FACC, FAHA, FCCP, Chair*; Stephen L. Archer, MD, FACC, FAHA†; David B. Badesch, MD, FCCP‡; Robyn J. Barst, MD, FACC, FAHA, FCCP†; Harrison W. Farber, MD, FAHA, FCCP†; Jonathan R. Lindner, MD, FACC; Michael A. Mathier, MD, FACC*; Michael D. McGoon, MD, FACC, FCCP§; Myung H. Park, MD, FACC*; Robert S.(More)
In the adult heart, a variety of stresses induce re-expression of a fetal gene program in association with myocyte hypertrophy and heart failure. Here we show that histone deacetylase-2 (Hdac2) regulates expression of many fetal cardiac isoforms. Hdac2 deficiency or chemical histone deacetylase (HDAC) inhibition prevented the re-expression of fetal genes(More)
BACKGROUND In hypertrophic cardiomyopathy, ejection fraction is normal or increased, and force-length relations are reduced. However, three-dimensional (3D) motion and deformation in vivo have not been assessed in this condition. We have reconstructed the 3D motion of the left ventricle (LV) during systole in 7 patients with hypertrophic cardiomyopathy(More)
Doppler echocardiography is commonly used to estimate systolic pulmonary artery pressure and to diagnose pulmonary hypertension, but data relating to its utility in patients with advanced lung disease are limited. In a cohort study of 374 lung transplant candidates, the performance characteristics of echocardiography compared with right heart(More)
The structural integrity of the heart is maintained by the end-to-end connection between the myocytes called the intercalated disc. The intercalated disc contains different junctional complexes that enable the myocardium to function as a syncytium. One of the junctional complexes, the zonula adherens or adherens junction, consists of the cell adhesion(More)
ACCF Task Force Members: Robert A. Harrington, M.D., F.A.C.C. Chair, Eric R. Bates, M.D., F.A.C.C., Charles R. Bridges, M.D., M.P.H., F.A.C.C., Mark J. Eisenberg, M.D., M.P.H., F.A.C.C., Victor A. Ferrari, M.D., F.A.C.C., Mark A. Hlatky, M.D., F.A.C.C., Sanjay Kaul, M.B.B.S., F.A.C.C., Jonathan R. Lindner, M.D., F.A.C.C.3 David J. Moliterno, M.D., F.A.C.C.,(More)
Apreliminary report on medical radiation exposures to the US population based on publicly available sources of data estimated that the collective dose received from medical uses of radiation has increased by 700% between 1980 and 2006.1 Computed tomography (CT) has had an annual growth rate of 10% per year and accounted for 50% of the collective dose in(More)
Activation of multiple pathways is associated with cardiac hypertrophy and heart failure. Repression of antihypertrophic pathways has rarely been demonstrated to cause cardiac hypertrophy in vivo. Hop is an unusual homeodomain protein that is expressed by embryonic and postnatal cardiac myocytes. Unlike other homeodomain proteins, Hop does not bind DNA.(More)
Lymphatic vessels develop from specialized endothelial cells in preexisting blood vessels, but the molecular signals that regulate this separation are unknown. Here we identify a failure to separate emerging lymphatic vessels from blood vessels in mice lacking the hematopoietic signaling protein SLP-76 or Syk. Blood-lymphatic connections lead to embryonic(More)