Victor Chiang

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The osteocyte network is recognized as the major mechanical sensor in the bone remodeling process, and osteocyte-osteoblast communication acts as an important mediator in the coordination of bone formation and turnover. In this study, we developed a novel 3D trabecular bone explant co-culture model that allows live osteocytes situated in their native(More)
Osteocytes, regarded as the mechanical sensor in bone, respond to mechanical stimulation by activating biochemical pathways and mediating the cellular activities of other bone cells. Little is known about how osteocytic networks respond to physiological mechanical stimuli. In this study, we compared the mechanical sensitivity of osteocytic and osteoblastic(More)
Although epigenetic control of stem cell fate choice is well established, little is known about epigenetic regulation of terminal neuronal differentiation. We found that some differences among the subtypes of Caenorhabditis elegans VC neurons, particularly the expression of the transcription factor gene unc-4, require histone modification, most likely H3K9(More)
Two genes, relA and spoT, are known to be responsible for the production of ppGpp when E. coli cells undergoing amino acid starvation initiate the stringent response. In this modified state, cells have been reported to up-regulate processes which confer resistance to antibiotics. However, the individual contribution of relA was not separated from potential(More)
Rainwater harvesting systems (RWHSs), a pilot-scale one (PSR) and a full-scale one (FSR), at a university campus in Taipei were assessed. Characteristics of harvested rainwater were analyzed, including pH, electrical conductivity (EC), turbidity, alkalinity, dissolved organic carbon (DOC), total coliform (TC), concentration of 14 metals (Al, Ca, K, Mg, Na,(More)
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