Victor C . Li

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It has long been the dream of biologists to map gene expression at the single-cell level. With such data one might track heterogeneous cell sub-populations, and infer regulatory relationships between genes and pathways. Recently, RNA sequencing has achieved single-cell resolution. What is limiting is an effective way to routinely isolate and process large(More)
A review of the basic theories of scaling in solid mechanics is presented. The problem of scaling is approached through dimensional analysis, laws of thermodynamics and asymptotic matching. Definitive conclusions on the relative importance of various sources of size effect (energy release, Weibull statistics, and crack fractality) tlrc drawn. The size(More)
Attainment of the differentiated state during the final stages of somatic cell differentiation is closely tied to cell cycle progression. Much less is known about the role of the cell cycle at very early stages of embryonic development. Here, we show that molecular pathways involving the cell cycle can be engineered to strongly affect embryonic stem cell(More)
This paper overviews Engineered Cementitious Composites (ECC) as an emerging construction material. Emphasis is placed on the accumulated knowledge on durability, safety, and sustainability of reinforced ECC (R/ECC) structures, recognizing that the concrete of the future must meet these characteristics. In light of recent and future full-scale field(More)
In somatic cells, the length of the G1 phase of the cell cycle is tightly linked to differentiation, and its elongation can drive differentiation in many cases. Although it has been suggested that the situation is very similar in embryonic stem cells (ESCs), where a rapid cell cycle and a short G1 phase maintain the pluripotent state, evidence has been(More)
A single fiber pullout test was used in this study to measure the bond properties of polyvinyl alcohol fibers that are available at various diameters in a mortar matrix. Despite short fiber embedment lengths, the small diameter fibers ruptured during the pullout tests. However, it is shown that even if full fiber pullout is not achieved, it is still(More)
ACI Materials Journal, V. 105, No. 6, November-December 2008. MS No. M-2007-388 received November 21, 2007, and reviewed under Institute publication policies. Copyright © 2008, American Concrete Institute. All rights reserved, including the making of copies unless permission is obtained from the copyright proprietors. Pertinent discussion including authors’(More)
Proper cell-cycle transitions are driven by waves of ubiquitin-dependent degradation of key regulators by the anaphase-promoting complex (APC) and Skp1-Cullin1-F-box (SCF) E3 ubiquitin ligase complexes. But precisely how APC and SCF activities are coordinated to regulate cell-cycle progression remains largely unclear. We previously showed that APC/Cdh1(More)