Victor A. Zuev

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A steady and long-term increase of the endogenous serotonine concentration in the lungs, spleen, and brain achieved by administration of nontoxic doses of indopan, an inhibitor of monoamineoxidase, caused a significant decrease of resistance of animals to influenza virus in acute infection. After natural route of inoculation with 20 LD50 of the allantoic(More)
The brain tissue of aging mice shows a factor that stimulates the proliferation of cells of glial origin both in primarily trypsinized and inoculated cultures. This factor that is likely to be of peptide origin is characterized by pronounced accumulation dynamics with increasing age in mammals, by unusually high thermal stability and by its possible(More)
Single intraperitoneal injection of splenic lymphoid cells from 20-month-old mice to 2-month-old syngeneic mice (similarly as 5-day injections of purified brain extract) leads to preterm (4 months earlier than in the control) appearance of aging factor in the blood (the main sign of old age). Combined injections of brain extract and splenic lymphoid cells(More)
Tissue renewal is the known phenomenon, when the progeny of resident or circulated stem cells (SC) replaces the vanishing cells. The delivery of stem cells via circulation should result in stem cell homing and differentiation into wide variety of tissues and gives promise as therapy for many diseases of tissue failure including aging itself. To test this(More)
Extract from the brain of young mice produced weak cytoproliferative effect on cultured glial cells, while brain extract from old mice 3–4- and 30–60-fold stimulated glial proliferation in primary and passaged cell cultures, respectively.