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OBJECTIVE To evaluate the disease burden of upper respiratory infections in elderly people living at home. DESIGN Prospective surveillance of elderly people. INTERVENTION None. SETTING Leicestershire, England SUBJECTS 533 subjects 60 to 90 years of age. MAIN OUTCOME MEASURES Pathogens, symptoms, restriction of activity, duration of illness,(More)
OBJECTIVE To determine whether people whose marital partners have depression, diabetes, hypertension, ischaemic heart disease, stroke, hyperlipidaemia, peptic ulcer disease, or asthma or chronic obstructive pulmonary disease are at increased risk of the same disease. DESIGN Cross sectional study. SETTING 10 practices from the Trent Focus Collaborative(More)
OBJECTIVE To assess the role of rhinoviruses in elderly people living in the community. DESIGN Prospective community based surveillance of elderly people, without intervention. Subjects were telephoned weekly to identify symptomatic upper respiratory tract infections. Symptoms and impact of illnesses were monitored, and specimens were collected for(More)
BACKGROUND Prescribing drugs to support smoking cessation is one of the most cost effective interventions in primary care, but there is evidence they are underused. Little is known about how far guidelines have been adopted. AIMS To examine the context in which nicotine replacement therapy (NRT) and bupropion are prescribed in UK general practice and(More)
BACKGROUND Corticosteroids and antiviral agents are widely used to treat the early stages of idiopathic facial paralysis (i.e., Bell's palsy), but their effectiveness is uncertain. METHODS We conducted a double-blind, placebo-controlled, randomized, factorial trial involving patients with Bell's palsy who were recruited within 72 hours after the onset of(More)
OBJECTIVES To determine whether paperless medical records contained less information than paper based medical records and whether that information was harder to retrieve. DESIGN Cross sectional study with review of medical records and interviews with general practitioners. SETTING 25 general practices in Trent region. PARTICIPANTS 53 British general(More)
AIM To apply in practice a series of validated indicators for preventable drug related morbidity (PDRM). DESIGN A pilot study to identify retrospectively potential PDRM events over a 2 year 3 month time frame using the MIQUEST computer software program. SUBJECTS AND SETTING The electronic patient record of all patients aged 18 years and over in nine(More)
BACKGROUND The polymerase chain reaction has improved the detection of picornaviruses and rhinoviruses and our understanding of their role in reversible airways disease. The effects of colds on lower respiratory morbidity and bacterial colonisation in cystic fibrosis remain uncertain. METHODS Children with cystic fibrosis were evaluated regularly in the(More)
BACKGROUND When interpreting results of studies undertaken by research networks we need to know how representative volunteer practices and their registered patients are of the total population of practices and patients in their locality. AIM To compare the following in research and non-research general practices in one region: practice and population(More)
OBJECTIVE To determine whether oral prednisolone or aciclovir, used separately or in combination, early in the course of Bell's palsy, improves the chances of recovery at 3 and 9 months. DESIGN A 2 x 2 factorial randomised double-blind trial. Patients were randomly assigned to treatment by an automated telephone service using a permuted block(More)