Vicky Griffiths

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AIMS Biventricular (BiV) pacing and left univentricular (LUV) pacing can each produce clinical benefits in heart failure. The impact of modern refinements in pacing optimization on the relative benefits of these two modes is unknown. We aimed to compare these two modes in patients with heart failure, using Echo-based optimization of each pacing mode. (More)
Shallow foundation designs are typically governed either by settlement, a serviceability limit state, or by bearing capacity, an ultimate limit state. While geotechnical engineers have been designing against these limit states for over half a century, it is only recently that they have begun to migrate towards reliability-based designs. At the moment,(More)
In order to control serviceability problems arising from excessive settlement of shallow footings, geotechnical design codes generally include specifications regarding maximum settlement which often govern the footing design. Once the footing has been designed and constructed, the actual settlement it experiences on a real three-dimensional soil mass can be(More)
1. The results of molecular orbital (MO) calculations, by the MINDO/3 method, on DNA bases, are reported; which point to a radical mechanism of alkylation. 2. Molecular electrostatic potential energy maps indicate propensity for alkylation by N-methyl-N-nitrosourea at key atoms on DNA bases. 3. A correlation between the MO-derived parameters net atomic(More)
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