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BACKGROUND Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Progesterone has been shown to improve neurologic outcome in multiple experimental models and two early-phase trials involving patients with TBI. METHODS We conducted a double-blind, multicenter clinical trial in which patients with severe, moderate-to-severe, or(More)
We analyze a recently proposed temporal centrality measure applied to an empirical network based on person-to-person contacts in an emergency department of a busy urban hospital. We show that temporal centrality identifies a distinct set of top-spreaders than centrality based on the time-aggregated binarized contact matrix, so that taken together, the(More)
BACKGROUND Alteration in menstrual cycle function is suggested among rhesus monkeys and humans exposed to polybrominated biphenyls (PBBs) and structurally similar polychlorinated biphenyls (PCBs). The feedback system for menstrual cycle function potentially allows multiple pathways for disruption directly through the hypothalamic-pituitary-ovarian axis and(More)
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