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rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome
We introduce RNA G-quadruplex sequencing (rG4-seq), a transcriptome-wide RNA G-quadruplex (rG4) profiling method that couples rG4-mediated reverse transcriptase stalling with next-generationExpand
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Whole genome experimental maps of DNA G-quadruplexes in multiple species
Abstract Genomic maps of DNA G-quadruplexes (G4s) can help elucidate the roles that these secondary structures play in various organisms. Herein, we employ an improved version of a G-quadruplexExpand
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Machine learning model for sequence-driven DNA G-quadruplex formation
We describe a sequence-based computational model to predict DNA G-quadruplex (G4) formation. The model was developed using large-scale machine learning from an extensive experimental G4-formationExpand
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High-resolution sequencing of DNA G-quadruplex secondary structures in the human genome
This is the author accepted manuscript. The final version is available from NPG via http://dx.doi.org/10.1038/nbt.3295
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Whole genome experimental maps of DNA G-quadruplexes in multiple species.
The S.B. research group is supported by programme grant funding from Cancer Research UK (C9681/A18618), European Research Council Advanced Grant No. 339778, a Wellcome Trust Senior Investigator AwardExpand
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Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter
Abstract Poly (ADP-ribose) polymerase 1 (PARP1) has emerged as an attractive target for cancer therapy due to its key role in DNA repair processes. Inhibition of PARP1 in BRCA-mutated cancers hasExpand
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Single Molecule Optical Determination of Bestrophin Stoichiometry
infectious. The crowded environment in the 100-nm sized viral particle makes it impossible for the AVP proteins to utilise regular three-dimensional diffusion to find the large number of proteaseExpand
Solution Structure and Dynamics of a Plant Pathogen Effector
Plant diseases account for at least $220 billion of crop losses worldwide every year, and have a significant impact on global food security and bio-fuel availability. Bacterial, oomycetes and fungiExpand
Structure of a G-quadruplex