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Four base recognition by triplex-forming oligonucleotides at physiological pH
BAU, MeP and APP retain considerable selectivity, and single base pair changes opposite these residues cause a large reduction in affinity, in contrast, S is less selective and tolerates CG pairs as well as TA.
Selectivity and affinity of triplex-forming oligonucleotides containing 2'-aminoethoxy-5-(3-aminoprop-1-ynyl)uridine for recognizing AT base pairs in duplex DNA.
- S. Osborne, Vicki E. C. Powers, David A Rusling, O. Lack, K. Fox, T. Brown
- Chemistry, BiologyNucleic acids research
These modified triplex-forming oligonucleotides retain exquisite sequence specificity, with enhanced discrimination against YR base pairs (especially CG).
First synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine
Fluorescent properties of DNA base analogue tC upon incorporation into DNA — negligible influence of neighbouring bases on fluorescence quantum yield
- P. Sandin, L. M. Wilhelmsson, P. Lincoln, Vicki E. C. Powers, T. Brown, B. Albinsson
- Chemistry, PhysicsNucleic acids research
- 7 September 2005
The results presented here together with previous work show that tC is a very good C-analogue that induces minimal perturbation to the native structure of DNA and is thus highly interesting in a range of applications for studying e.g. structure, dynamics and kinetics in nucleic acid systems.
A new and highly expedient synthesis of pyrido[2,3-d]pyrimidines
Stable recognition of TA interruptions by triplex forming oligonucleotides containing a novel nucleoside.
(2AE)S is the best nucleoside described so far for recognition of TA within a triple-helix target and the selectivity for TA improves with increased pH.
Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues.
- Rohan T Ranasinghe, David A Rusling, Vicki E. C. Powers, K. Fox, T. Brown
- Chemistry, BiologyChemical communications
- 16 May 2005
Substituted 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues have been synthesised from 5-alkynyl-uridine derivatives and found to selectively bind CG inversions with enhanced affinity compared to T.
Addressable high-information-density DNA nanostructures
Triplex staples: DNA double-strand cross-linking at internal and terminal sites using psoralen-containing triplex-forming oligonucleotides.
- Hong Li, Victoria J Broughton-Head, T. Brown
- Chemistry, BiologyBioconjugate chemistry
- 27 October 2006
UV irradiation of triplex-forming oligonucleotides (TFOs) containing internally attached psoralens produces photoadducts at TpA steps within target duplexes, thus relaxing the constraints on selection of psoralen target sequences.
Combining nucleoside analogues to achieve recognition of oligopurine tracts by triplex‐forming oligonucleotides at physiological pH