Vibeke Secher Dam

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This review summarizes the current knowledge of Cl(-) transport in vascular smooth muscle cells (VSMCs). VSMCs accumulate Cl(-) intracellularly using two secondary-active transport mechanisms. The Cl(-) equilibrium potential is more positive than the resting membrane potential enabling Cl(-) to be a depolarizing ion upon activation of a Cl(-) conductance.(More)
AIMS We have previously characterized a cGMP-dependent Ca(2+)-activated Cl(-) current in vascular smooth muscle cells (SMCs) and have shown its dependence on bestrophin-3 expression. We hypothesize that this current is important for synchronization of SMCs in the vascular wall. In the present study, we aimed to test this hypothesis by transfecting rat(More)
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