Vibeke Andresen

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Disease development in human T-cell leukemia virus type 1 (HTLV-1)-infected individuals is positively correlated with the level of integrated viral DNA in T cells. HTLV-1 replication is positively regulated by Tax and Rex and negatively regulated by the p30 and HBZ proteins. In the present study, we demonstrate that HTLV-1 encodes another negative regulator(More)
The identification of the genes necessary for human T-cell leukemia virus (HTLV-1) persistence in humans may provide targets for therapeutic approaches. We demonstrate that ablation of the HTLV-1 genes encoding p12, p30, or the HBZ protein, does not affect viral infectivity in rabbits and in this species, only the absence of HBZ is associated with a(More)
The carboxy-terminal truncated p53 alternative spliced isoforms, p53β and p53γ, are expressed at disparate levels in cancer and are suggested to influence treatment response and therapy outcome. However, their functional role in cancer remains to be elucidated. We investigated their individual functionality in the p53(null) background of cell lines H1299(More)
Human T-cell Leukemia Virus type-1 (HTLV-1) is highly immunogenic and has low variability so tight regulation of its expression is essential for virus maintenance in vivo. HTLV-1 replication is positively regulated by Tax and Rex, and negatively by the p30 and HBZ proteins. Here, we demonstrate that HTLV-1 encodes another negative regulator of virus(More)
Human T cell leukemia virus type 1 (HTLV-1) gene expression is controlled by the key regulatory proteins Tax and Rex. The concerted action of these proteins results in a two-phase kinetics of viral expression that depends on a time delay between their action. However, it is difficult to explain this delay, as Tax and Rex are produced from the same mRNA. In(More)
Mutated nucleophosmin 1 (NPM1) acts as a proto-oncogene and is present in ~30% of patients with acute myeloid leukemia (AML). Here we examined the in vitro and in vivo anti-leukemic activity of the NPM1 and chromosome region maintenance 1 homolog (CRM1) interacting natural product avrainvillamide (AVA) and a fully syntetic AVA analog. The NPM1-mutated cell(More)
The HTLV-1 ORF-1-encoded p12 protein induces T-cell activation and proliferation, while the cleaved p8 protein downregulates TCR signaling. In this study, we investigated whether there is a correlation between genetic variation within ORF-1 and the clinical status or pro-viral load in HTLV-1 infected individuals. The ORF-1 gene was amplified by PCR from(More)
The tunneling nanotube (TNT) is a novel type of cell-to-cell communicator, 50-2 nm in diameter, F-actin containing structure connecting two or more cells. TNTs have been observed in a variety of cells to transport different components such as mitochondria, cell membrane components, multi-resistance genes and pathogens (like retroviruses and bacteria). The(More)
Human T-cell Lymphotropic Virus type-1 (HTLV-1) is the causative agent of an aggressive malignancy of CD4 + T lymphocytes. It is believed that the viral transactiva-tor Tax-1 is a major player in T-cell transformation. Thus, targeting Tax-1 protein is regarded as a possible strategy to arrest viral replication and ultimately to counteract neoplastic(More)
2003 Acknowledgements I would like to thank my supervisor, professor Dag E. Helland, for giving me something to do, for supporting me in, and never abandoning the hope that I would eventually finish, doing it; also my assistant supervisor, professor Anne Marie Szilvay, for encouragement and for pushing me, especially the latter; I sincerely doubt you would(More)