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The behavioral responses of rats to uni- or bilateral microinjections of the octapeptide cholecystokinin (CCK-8) into the left and/or right or both nucleus accumbens (NA) or amygdalae were studied. There were two main findings of effects of microinjections of CCK-8 into NA. First, bilateral injections of CCK-8 into NA dose-dependently decreased the(More)
Prolonged social isolation of Wistar rats produces various neurochemical, neuroendocrine and behavioral changes. Some of isolated rats exhibit interspecies aggressive behavior (mouse-killing). It is suggested that social isolation leads to a stress-like state of rats. On the other hand, the participation of endogenous opioid mechanisms in stress is well(More)
In experiments on 2-, 10- and 22-month old rats, it was found that essential age-related changes occurred in the brain level of biogenic monoamines (BMA) and in the monoamine oxidase (MAO) activity. In 22-month old rats the levels of dopamine (DA), noradrenaline (NA) and serotonin (5-HT) markedly declined in most of the brain structures studied. 5-HT(More)
1. Behavioral responses to unilateral and bilateral microinjections of the 5-HT1A receptor antagonist, NAN190 [1-(2-methoxyphenyl)-4-[4-(2-phthalimido) butyl]piperazine hydrobromide] (1 microgram), into the hippocampal CA1 area of male Wistar rats were studied. 2. NAN190 decreased locomotor activity (the number of horizontal and vertical movements). The(More)
The effect of alcohol-aqueous extract (1:1) from Rhodiola rosea L. roots on the processes of learning and memory is studied on rats. Several methods of active avoidance with negative and positive reinforcements are used, as well as of passive avoidance. Using the maze-method with negative (punitive) reinforcement, it has been found that Rhodiola extract in(More)
The study was performed upon three groups of 12-week-old male rats. The first group of rats received ethanol/9 g/kg/day as 6% aqueous solution/during pregnancy and lactation, the second group received ethanol only during lactation and the third group, controls, received equicaloric sucrose solution. The concentrations of LPO products were determined in the(More)
Ethopharmacological techniques were used to study the behaviour of the offspring of mice treated with different drugs before and after parturition. The "standard opponent" test was used and the animal's behaviour was recorded on videocassettes. It was found that ethyl alcohol, glutamate, cyproterone acetate, medroxyprogesterone acetate, corticosterone and(More)
The amount of acetylcholine (ACh) released in perplex cylinders filled with 0.5 ml eserinized Ringer solution and placed on the exposed rat cerebral cortex was determined every 10 min. For the purpose bioassay on leech dorsal muscle was used. ACh was calculated in pmoles/cm2 min-1. It was found that diazepam decreased by 30 per cent, hyoscine increased by(More)
In experiments on young (aged 3 months) and old (aged 26 months) rats, using some conditioned-reflex methods with punishment or positive reinforcement for active and passive avoidance (shuttle-box, step-down, step-through, and water maze), we studied the effects of the standardized extracts of Panax ginseng (G115), Ginkgo biloba (GK501) and their(More)
Quantitative and qualitative changes in the synapses in stratum lacunosum-moleculare of rat hippocampus following pre- and postnatal alcohol exposure were studied. Dense and lamellar bodies, damaged mitochondria, autophagic vacuoles and dilatated cisterns of the smooth endoplasmic reticulum were seen in axons and dendrites. The enlarged glial processes were(More)