Veronika Volgger

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BACKGROUND In this trial, the ability of confocal laser endomicroscopy (CLE), a new imaging modality with a cellular resolution, to further differentiate primary flat lesions of the larynx was evaluated. METHODS First, an optical coherence tomography was used to filter out normal tissue and carcinoma. All other lesions (30 lesions in 19 patients) were(More)
BACKGROUND Acquired subglottic stenosis (SGS) most commonly results from prolonged endotracheal intubation and is a diagnostic challenge in the intubated child. At present, no imaging modality allows for in vivo characterization of subglottic microanatomy to identify early signs of acquired SGS while the child remains intubated. Fourier domain optical(More)
BACKGROUND AND OBJECTIVE Laryngeal lesions are usually investigated by microlaryngoscopy, biopsy, and histopathology. This study aimed to evaluate the combined use of Narrow Band Imaging (NBI) and High-Speed Imaging (HSI) in the differentiation of glottic lesions in awake patients. STUDY DESIGN Prospective diagnostic study. MATERIALS AND METHODS(More)
PURPOSE OF REVIEW Confocal laser endomicroscopy (CLE) is a novel, noninvasive technique used to obtain microanatomical images of the inner lining of hollow organs. It has been used in a variety of clinical specialties to aid in the diagnosis and treatment planning of inflammatory and neoplastic processes. Our intent is to provide an up-to-date review of the(More)
BACKGROUND This study evaluated the capability of optical coherence tomography (OCT) to differentiate premalignant and early malignant lesions of the upper aerodigestive tract (UADT). METHODS An OCT screening was performed in 52 healthy volunteers. Epithelial thicknesses on 38 OCT images and histopathological slides were correlated. One hundred primary(More)
The gold standard in the treatment of (pre)malignancies of the upper aerodigestive tract (UADT) is either surgery or (chemo)radiotherapy. Nevertheless, there are special indications where an alternative treatment, such as photodynamic therapy (PDT), might be as effective for and better tolerated by the patients concerned. This article aims to present a(More)
Methods 61 patients with a total of 82 primary leukoplakic or erythroplakic mucosal lesions of the upper aerodigestive tract (OADT) were prospectively examined using an in-vivo, time-domain OCT (Niris®, Imalux Corporation, USA; lateral resolution 25 μm / axial resolution 15 μm) so far. The results were subsequently correlated to histopathology of tissue(More)
Optische Diagnoseverfahren können die Tumorfrühdiagnostik im oberen Luft-Speise-Weg erleichtern und verbessern, haben sich jedoch bisher in der klinischen Routine nicht durchsetzen können. Ziel war die Definition der Probleme, die den Routineeinsatz optischer Diagnoseverfahren bisher verhindern, sowie Aufführung und Erläuterung möglicher, zukunftsweisender(More)
Detection of an early stage of subglottic edema is vital for airway management and prevention of stenosis, a life-threatening condition in critically ill neonates. As an observer for the task of diagnosing edema in vivo, we investigated spatiotemporal correlation (STC) of full-range optical coherence tomography (OCT) images acquired in the rabbit airway(More)
Intraoperative detection of residual malignant cells at tumor margins following excision of primary tumors could help improving surgery and thus patients' outcome. The feasibility of the tumor antigens epidermal growth factor receptor (EGF-R) and epithelial cell adhesion molecule (EpCAM) for antibody-dependent confocal laser scanning endomicroscopy(More)