Veronika Schmitt

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Blood membrane interactions in hemodialysis have been shown to trigger complement (C) activation. As indicators of C-activation the anaphylatoxins (C3a and C5a) are problematical because of methodological difficulties and their kinetic properties. We developed a sensitive and specific micro-ELISA using a monoclonal antibody against neoantigens on the(More)
Ischemia-reperfusion (I/R) is associated with changes in energy metabolism in the heart. However, the majority of studies have focused on examining rates and extent of fatty acid (FA) oxidation, with limited emphasis on FA delivery. We examined the influence of acute myocardial I/R on coronary lipoprotein lipase (LPL), the key enzyme responsible for(More)
1 Faculty of Pharmaceutical Sciences , The University of British Columbia, Vancouver, BC , Canada 2 Child and Family Research Institute , Vancouver, BC , Canada 3 Department of Pharmacy , Children ’ s and Women ’ s Health Centre of British Columbia, Vancouver, BC , Canada 4 Departments of Mechanical and Electrical and Computer Engineering , The University(More)
This study compared drug concentration-time profiles in interstitial fluid (ISF) and blood, using an established animal model and a comprehensive panel of drugs, to examine the feasibility of therapeutic drug monitoring (TDM) in ISF. An intravenous bolus of vancomycin, gentamicin, tacrolimus, cyclosporine, mycophenolate, valproic acid, phenobarbital,(More)
Hollow microneedles can overcome the stratum corneum (SC) barrier and deposit a compound directly into the viable epidermis or the dermis, unlike adhesive patches that rely on drug diffusion across the SC. The traditional one-dimensional methods used to study the diffusivity of drugs across the skin layers are not very accurate for hollow microneedles,(More)
Obesity is a state of positive energy balance where excess white adipose tissue accumulates to the detriment of metabolic health. Improving adipocyte function with systemic administration of thiazolidinediones (TZDs) improves metabolic outcomes in obesity, however TZD use is limited clinically due to undesirable side effects. Here we evaluate magnetic(More)
Magnetic particles were modified with covalently-bound surface heparin (HEPMag). The amount and activity of bound heparin was investigated with the toluidine blue, APTT, Kinetichrome Anti-IIa and western blot assays. The particles bound 40 μg/mg (0.42 U/mg) and exhibited excellent anticoagulant activity. However, the activity was 5x less than that of free(More)
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