Veronica Zanon

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Early T-cell reconstitution following allogeneic transplantation depends on the persistence and function of T cells that are adoptively transferred with the graft. Posttransplant cyclophosphamide (pt-Cy) effectively prevents alloreactive responses from unmanipulated grafts, but its effect on subsequent immune reconstitution remains undetermined. Here, we(More)
Professor Piergiorgio Data, who passed away in September 2005, was a professor of physiology and of diving and hyperbaric medicine. The Diving and Subaquatic Activities Postgraduate Course of the Medical School at Gabriele D’Annunzio University, in Chieti, a small city in central Italy, started as a result of his extremely enthusiastic and charismatic care(More)
The treatment of many hematological diseases benefits from myeloablative or non-myeloablative conditioning regimens followed by SCT or BMT. HLA-matched donors are preferred but not always available. Instead, haploidentical donors can be rapidly identified. Unmanipulated haploidentical BMT (haploBMT) with non-myeloablative conditioning and post-transplant Cy(More)
Human T memory stem (TSCM ) cells with superior persistence capacity and effector functions are emerging as important players in the maintenance of long-lived T-cell memory and are thus considered an attractive population to be used in adoptive transfer-based immunotherapy of cancer. However, the molecular signals regulating their generation remain poorly(More)
Following recognition of the cognate antigen, naïve T cells differentiate in a diverse progeny of memory T cells which differ at the phenotypic, gene expression and metabolic level. These molecular differences are at the basis of discrete functionality, migratory capacity and persistence in the long-term. Such a division of labor benefits adoptive T cell(More)
1 Laboratory of Translational Immunology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy 2 Institution of Infection and Immunity, Cardiff University School of Medicine, Cardiff, Wales, UK 3 Translational Tumor Immunology Group, Ludwig Center for Cancer Research, Epalinges, Switzerland 4 Unit of Clinical and Experimental Immunology, Humanitas(More)
Flow cytometry is a powerful and robust technology for detecting and monitoring multiple markers at the level of single cells. Since its early development, flow cytometry has been used to assess heterogeneity in a cell suspension. Over the years, the increasing number of parameters that could be included in a single assay combined with physical separation(More)
Mammalian aging may be viewed as a reduction in the capacity to adequately maintain tissue homeostasis or to repair tissues after injury(Sharpless and DePinho, 2007). When homeostatic control diminishes to the point at which tissue/organ integrity and function are no longer sufficiently maintained, physiological decline develops, and aging becomes apparent.(More)
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