Vernon J. Perez

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Groups of 4-day-old Cox Swiss albino mice were injected once subcutaneously with monosodium glutamate at several doses between 0.2 and 0.5 mg/g body weight. Glutamate, at a dose of 0.35 mg/g, produced neuronal necrosis of a very limited nature in only 60% of the animals and was defined as the minimal effective neurotoxic dose in the 4-day-old mouse.(More)
A brain specific protein, 14-3-2, has been isolated from bovine brain by the use of ammonium sulfate precipitation, gel filtration on Sephadex G-150, and ion exchange chromatography on DEAE-cellulose and DEAE-Sephadex. It is an acidic protein, in agreement with the high content of glutamic and aspartic acid, that is composed of a single polypeptide chain of(More)
Phencyclidine (PCP) (5 mg/kg) was administered daily throughout gestation and pups were cross-fostered or fostered after birth. Prenatal weight gain, length of gestation, length of parturition, and the size and birth weight of the litters were not affected by PCP administration. No congenital malformations were evidence and the mother's health during(More)