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Here we demonstrate that miRNA regulation in marmoset (Callithrix jacchus) and C57/BL6 mouse EAE lesions largely resembles miRNA regulation in active human MS lesions. Detailed quantitative PCR analyses of the most up- and downregulated miRNAs of active human MS lesions in dissected lesions from marmoset EAE brains and inflamed spinal cords of EAE mice(More)
This study has focussed on a 10-item Brief Psychiatric Rating Scale (BPRS) subscale for the quantification of schizophrenic states. Seven psychiatrists interviewed jointly patients who all fulfilled the DSM-III criteria of schizophrenia, and in a subsequent pencil-and-paper procedure a judgment analysis was performed. The reliability analysis showed that(More)
Community-university partnerships are gaining momentum across the country as a powerful force for revitalizing communities, fostering civic engagement and strengthening the core missions of higher education. The landscape of community-university partnerships includes service-learning, community-based participatory research and partnerships focused on(More)
For my sister marianne. AFFIDAVIT Here I declare that my doctoral thesis entitled " Axonal degeneration and protection during early remyelination in multiple sclerosis and an animal model " has been written independently with no other sources and aids than quoted. (2012) MicroRNA regulation in experimental autoimmune encephalomyelitis in mice and marmosets(More)
In 103 schizophrenic patients we investigated the extent of practice needed in the use of the Brief Psychiatric Rating Scale (BPRS) to enable its reliability to be assessed. The agreement level of the 7 raters was analysed. Generally, the lowest mean agreement found was for the negative symptoms of the BPRS schizophrenia subscale. A high degree of agreement(More)
The cutaneous response to intradermal injection of 50 micrograms of histamine was studied in nonmedicated schizophrenic patients, schizophrenic patients treated with neuroleptic drugs, nonschizophrenic patients receiving neuroleptics, and nonmedicated controls. The diminished response previously reported in schizophrenic patients was not reproduced. Thus,(More)
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