Verena Amberger-Murphy

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BACKGROUND Glioblastoma (GBM), being a highly vascularised and locally invasive tumour, is an attractive target for anti-angiogenic and anti-invasive therapies. The GBM/endothelial cell response to gossypol/temozolomide (TMZ) treatment was investigated with a particular aim to assess treatment effects on cancer hallmarks. METHODS Cell viability,(More)
The main problem in the treatment of malignant astrocytomas is their invasive behaviour. Successful resection of the main tumour mass cannot prevent recurrence due to single cells invading the surrounding brain parenchyma at the time of diagnosis. The classical combination therapy, PCV (Procarbazine, CCNU and Vincristine) used for over 30 years; has shown(More)
Gliomas are thought to originate from neuroglial cells (e.g. astrocytes) or their progenitors. One of the main biological features of a glioma is the local invasion of its constituent neoplastic cells into the surrounding brain tissue. This invasive behaviour presents a major obstacle to an effective treatment of intrinsic brain tumours. Thus, the transient(More)
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