Vera Rogiers

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Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

Sarah Adler, David A Basketter, +52 authors J. Zaldivar
Archives of Toxicology
2011

The 7th amendment to the EU Cosmetics Directive prohibits to put animal-tested cosmetics on the market in Europe after 2013. In that context, the European Commission invited stakeholder bodies… (More)

Paracrine signaling through plasma membrane hemichannels.

Nan Wang, Marijke De Bock, +7 authors Luc Leybaert
Biochimica et biophysica acta
2013

Plasma membrane hemichannels composed of connexin (Cx) proteins are essential components of gap junction channels but accumulating evidence suggests functions of hemichannels beyond the communication… (More)

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity,…

Patricio Godoy, Nicola J. Hewitt, +90 authors Jan G. Hengstler
Archives of Toxicology
2013

This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules,… (More)

EEMCO guidance for the assessment of transepidermal water loss in cosmetic sciences.

Vera Rogiers
Skin pharmacology and applied skin physiology
2001

Measurement of transepidermal water loss (TEWL), based on the estimation of the water vapour gradient in an open chamber, is being used to support claims of cosmetics including product mildness,… (More)

Ca(2+) regulation of connexin 43 hemichannels in C6 glioma and glial cells.

Elke De Vuyst, Nan Wang, +10 authors Luc Leybaert
Cell calcium
2009

Connexin hemichannels have a low open probability under normal conditions but open in response to various stimuli, forming a release pathway for small paracrine messengers. We investigated… (More)

Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood-brain barrier permeability.

Marijke De Bock, Maxime Culot, +14 authors Luc Leybaert
Journal of cerebral blood flow and metabolism…
2011

The cytoplasmic Ca(2+) concentration ([Ca(2+)](i)) is an important factor determining the functional state of blood-brain barrier (BBB) endothelial cells but little is known on the effect of dynamic… (More)

Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity.

J P Hachem, Mao-Quiang Man, +6 authors Peter M Elias
The Journal of investigative dermatology
2005

We showed recently that short-term increases in stratum corneum (SC) pH are accompanied by minor alterations in permeability barrier homeostasis and SC integrity/cohesion. Since prolonged SC… (More)

Connexin 43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model

Elke Decrock, Elke De Vuyst, +11 authors Luc Leybaert
Cell Death and Differentiation
2009

Gap junctions (GJs) have been demonstrated to communicate cell death signals from apoptotic to healthy cells, thereby spatially extending apoptosis. Before being incorporated into GJs, hemichannels… (More)

A review of the implementation of the embryonic stem cell test (EST). The report and recommendations of an ECVAM/ReProTect Workshop.

Philip Marx-Stoelting, Els Adriaens, +19 authors Michael Schwarz
Alternatives to laboratory animals : ATLA
2009

Trichostatin a enhances gap junctional intercellular communication in primary cultures of adult rat hepatocytes.

Mathieu Vinken, Tom Henkens, +6 authors Vera Rogiers
Toxicological sciences : an official journal of…
2006

The effects of histone deacetylase inhibitor Trichostatin A (TSA) on connexin (Cx) expression and gap junctional intercellular communication (GJIC) were investigated in primary cultures of adult rat… (More)

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