Verónica Sanchez-Freire

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(D (D (Dav av avis is is))) S Sc ch ho hool ol ol o of f M Med d dici ci ine ne e, , , Da Da Davi vi vis, s, C C CA A A * Co Co Cont nt ntri ri ribu bu bute te ted d d eq eq equa ua uall ll lly y y Abstract: Background—Cardiotoxicity is a leading cause for drug attrition during pharmaceutical
The exact nature of the immune response elicited by autologous-induced pluripotent stem cell (iPSC) progeny is still not well understood. Here we show in murine models that autologous iPSC-derived endothelial cells (iECs) elicit an immune response that resembles the one against a comparable somatic cell, the aortic endothelial cell (AEC). These cells(More)
Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: Accession codes Sequencing data has been deposited in NCBI Biosample under accession number SAMN02708924. Competing Financial Interests The authors declare no competing financial(More)
S3 C ardiac toxicity is a major cause of drug attrition during preclinical development. In addition, the risk of drug-induced arrhythmia is the most common cause of restriction or withdrawal of drugs from the market. 3 Between 1990 and 2001, 8 noncardiovascular drugs were withdrawn at an estimated cost of $12 billion as a result of problems such as delayed(More)
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