Vennila Ponnusamy

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There has been a significant increase in premedication use for neonatal intubation in the UK over the past decade. We aimed to determine the adverse events during neonatal intubation using the most commonly used premedication regimen in the UK. We prospectively studied all intubations performed using morphine, suxamethonium and atropine during a 3-month(More)
Oxygen (O2) therapy delivered via infranasal cannulae is widely used to support breathing in term and preterm neonates and can be administered by high flow (HF) or low flow (LF). HF nasal therapy delivers heated, humidified, and blended O2/air via small calibre nasal cannulae at flow rates >1 L/min. The normal airway humidifies and warms inspired air to(More)
UNLABELLED A 6-week-old infant presenting with near-drowning was medically paralysed and ventilated on admission. Status epilepticus was found on cerebral function monitoring, without which the diagnosis would have been missed or delayed for many hours. This case illustrates the value of cerebral function monitoring for patients in intensive care, where(More)
PURPOSE OF REVIEW Neonates in intensive care are more susceptible to sepsis. Infection is commonly acquired via the transcutaneous portal. It is necessary to identify the most effective yet safest topical antiseptics for use in neonates to reduce nosocomial sepsis. RECENT FINDINGS Recent national surveys indicate that a wide range of topical antiseptic(More)
AIM The commonest mode of catheter colonisation is via the extraluminal route with skin bacteria. Catheter-related sepsis causes significant mortality and morbidity in neonates. Our aim was to study the relationships between culture-positive catheter exit site skin swabs, percutaneous central venous catheter segments and blood to determine the magnitude of(More)
OBJECTIVE Culture of percutaneous central venous line (PCVL) segments may assist the diagnosis of line colonisation and catheter-related sepsis (CRS). The authors aimed to determine if the diagnosis of CRS and colonisation of PCVLs in neonates is improved by the culture of the proximal and middle segments of the line in addition to the tip. PATIENTS AND(More)
Background:The potential of microRNAs (miRNAs) as bedside biomarkers in selecting newborns with hypoxic-ischemic encephalopathy (HIE) for neuroprotection has yet to be explored. Commonly, blood-based biomarker tests use plasma or serum which don’t allow evaluation of both intracellular and extracellular changes.Methods:We describe a technique to extract and(More)
Background and aim: Insertion of percutaneous central venous lines (PCVLs) is an everyday procedure in the neonatal unit. The presence of PCVL is an important risk factor for catheter-related sepsis. We aimed to study the characteristics of infants with indwelling PCVLs who develop catheter-associated sepsis (CAS).Design and Methods: Prospective study in(More)