Venkatesh R. Chari

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Artificial larynges provide a means of verbal communication for people who have either lost or are otherwise unable to use their larynges. Although they enable adequate communication, the resulting speech has an unnatural quality and is significantly less intelligible than normal speech. One of the major problems with the widely used Transcutaneous(More)
To test the hypothesis that the lower limbs contribute to sitting balance when a person reaches forward, we measured the limits of forward reach in 20 healthy volunteers. While sitting on the buttocks alone (ischial support) or with the thighs also supported and with both feet on, one foot off, or both feet off the floor (in a balanced order), each subject(More)
The androgen receptor (AR) is essential for diverse aspects of prostate development and function. Molecular mechanisms by which prostate cancer (PC) cells redirect AR signaling to genes that primarily support growth are unclear. A systematic search for critical AR-tethering proteins led to ELK1, an ETS transcription factor of the ternary complex factor(More)
The present study deals with 30 patients with cirrhosis of the liver and 12 patients with infective hepatitis who were studied clinically, neurophysiologically and histopathologically for the presence of neuropathy. Simultaneously, 13 healthy individuals were evaluated as controls. Clinical evidence of neuropathy was found in 63.3% of the patients with(More)
Arti cial larynxes enable adequate communication for people who are unable to use their larynxes. However, the resulting speech has an unnatural quality and is signi cantly less intelligible than normal speech. One of the major problems with the widely-used Transcutaneous Arti cial Larynx (TAL) is the presence of a steady background noise due to the leakage(More)
The ETS domain transcription factor ELK1 is in a repressive association with growth genes and is transiently activated through phosphorylation by ERK1/2. In prostate cancer (PCa) cells the androgen receptor (AR) is recruited by ELK1, via its amino-terminal domain (A/B), as a transcriptional co-activator, without ELK1 hyper-phosphorylation. Here we elucidate(More)
Retinoic acid receptor alpha (RARα) selective compounds may guide the design of drugs that can be used in conjunction with hormonal adjuvant therapy in the treatment of breast cancer. Herein we report a modified synthesis of a known RARα antagonist, 2-fluoro-4-[[[8-bromo-2,2-dimethyl-4-(4-methylphenyl)chroman-6-yl]carbonyl]amino]benzoic acid and a synthesis(More)
The hypothesis that prostheses improve the forward reach of sitting lower-limb amputees was tested. While sitting with only ischial support, ten unilateral below-knee (BK) amputees could reach farther when they wore their prostheses than when they did not, when reaching at 45 degrees toward or away from the side of the amputation, with mean differences (+/-(More)
An adaptive enhancement procedure is presented which emphasizes continuant spectral features such as formant frequencies, by imposing frequency and amplitude continuity constraints on a short-time Fourier representation of the speech signal. At each point in the time-frequency field, the direction of maximum energy correlation is determined by the angle of(More)
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