Venkata S Bollimpelli

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Curcumin is known to have neuroprotective role and possess antioxidant, anti-inflammatory activities. Rotenone, a flavonoid induced neurotoxicity in dopaminergic cells is being widely studied in Parkinson's Disease (PD) research. In the present study, curcumin loaded lactoferrin nano particles prepared by sol-oil chemistry were used to protect dopaminergic(More)
Primary ventral mesencephalic (VM) neuronal cultures are gaining importance in the study of molecular mechanisms leading to Parkinson's disease and development of treatment strategies. In practice, these neurons are cocultured with glial cells, making assessment of neuronal specific proteomic and genomic analyses difficult. Hence, development of VM(More)
TopoisomeraseIIβ, an isoform of type II topoisomerase, was found to be functional in various viral infections. Its plausible role in HIV life cycle was also suggested earlier, but not clearly established. In the present study, we have investigated the role of TopoIIβ in HIV-1 infection by its gain and loss of function. Overexpression of TopoIIβ lead to an(More)
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