Vei H. Mah

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Abnormal phosphorylation of the microtubule associated protein tau component of neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) may result from alterations in protein kinase expression. Calcium/calmodulin dependent protein kinase II (CaM kinase II) has been shown to phosphorylate tau in vitro in such a way to decrease its electrophoretic(More)
The SENEX project is exploring knowledge representation in the neurobiology of ageing through object-oriented programming. SENEX is built from a classification structure of biologic entities and significant relationships among them. For example, an enzyme is an entity and an enzymatic reaction is a relationship among enzyme, cofactor(s), substrate(s) and(More)
The occurrence of mania in the elderly is under-estimated. Mania may inaugurate a late-onset bipolar illness, extend a unipolar depressive disorder or rarely continue a early-onset bipolar illness. Early-onset bipolar illness frequently disappear after 60 years or is prolonged by reccurrent depression. Late-onset bipolar illness may be preceded by slight(More)
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