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Randomized Aggregatable Privacy-Preserving Ordinal Response, or RAPPOR, is a technology for crowdsourcing statistics from end-user client software, anonymously, with strong privacy guarantees. In short, RAPPORs allow the forest of client data to be studied, without permitting the possibility of looking at individual trees. By applying randomized response in(More)
Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This(More)
The R package clValid contains functions for validating the results of a clustering analysis. There are three main types of cluster validation measures available, “internal”, “stability”, and “biological”. The user can choose from nine clustering algorithms in existing R packages, including hierarchical, K-means, self-organizing maps (SOM), and model based(More)
Researchers in the field of bioinformatics often face a challenge of combining several ordered lists in a proper and efficient manner. Rank aggregation techniques offer a general and flexible framework that allows one to objectively perform the necessary aggregation. With the rapid growth of high-throughput genomic and proteomic studies, the potential(More)
Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P =(More)
Mass spectrometry has been used in biochemical research for a long time. However, its potential for discovering proteomic biomarkers using protein mass spectra has aroused tremendous interest in the last few years. In spite of its potential for biomarker discovery, it is recognized that the identification of meaningful proteomic features from mass spectra(More)
Abstract: Techniques based on randomized response enable the collection of potentially sensitive data from clients in a privacy-preserving manner with strong local differential privacy guarantees. A recent such technology, RAPPOR [12], enables estimation of the marginal frequencies of a set of strings via privacy-preserving crowdsourcing. However, this(More)
QT interval variation is assumed to arise from variation in repolarization as evidenced from rare Na- and K-channel mutations in Mendelian QT prolongation syndromes. However, in the general population, common noncoding variants at a chromosome 1q locus are the most common genetic regulators of QT interval variation. In this study, we use multiple human(More)
MOTIVATION Gene association/interaction networks provide vast amounts of information about essential processes inside the cell. A complete picture of gene-gene associations/interactions would open new horizons for biologists, ranging from pure appreciation to successful manipulation of biological pathways for therapeutic purposes. Therefore, identification(More)
Tychele N. Turner1,2,3, Kamal Sharma4, Edwin C. Oh5, Yangfan P. Liu5, Ryan L. Collins6, Maria X. Sosa1,3, Dallas R. Auer1,3, Harrison Brand6,7, Stephan J. Sanders3,8, Daniel Moreno-De-Luca3,9, Vasyl Pihur1,3, Teri Plona10, Kristen Pike10, Daniel R. Soppet10, Michael W. Smith11, Sau Wai Cheung12, Christa Lese Martin3,13, Matthew W. State3,8, Michael E.(More)