Vasuki Himabindu Dandu

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Neurodegeneration with brain iron accumulation (NBIA) is a group of genetic disorders characterized by abnormal iron deposition in the basal ganglia. We report that de novo mutations in WDR45, a gene located at Xp11.23 and encoding a beta-propeller scaffold protein with a putative role in autophagy, cause a distinctive NBIA phenotype. The clinical features(More)
Neurodegenerative disorders with high iron in the basal ganglia encompass an expanding collection of single gene disorders collectively known as neurodegeneration with brain iron accumulation. These disorders can largely be distinguished from one another by their associated clinical and neuroimaging features. The aim of this study was to define the(More)
Beta-propeller protein-associated neurodegeneration: a new X-linked dominant disorder with brain iron accumulation Susan J. Hayflick, Michael C. Kruer, Allison Gregory, Tobias B. Haack, Manju A. Kurian, Henry H. Houlden, James Anderson, Nathalie Boddaert, Lynn Sanford, Sami I. Harik, Vasuki H. Dandu, Nardo Nardocci, Giovanna Zorzi, Todd Dunaway, Mark(More)
A 33-year-old African American woman was admitted with acute onset weakness involving all her extremities of 1-day duration. She experienced pain in her retrosternal and cervical regions, followed by acute onset of numbness and weakness of all her extremities with alteration in tone of her speech. Except for phentermine intake for obesity for the last 3(More)
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