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OBJECTIVE In mouse, PGC1-α overexpression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin. One prior(More)
CONTEXT Irisin has been proposed to be a myokine mediating the effect of exercise on adipocyte browning. The physiology of irisin in humans is not completely understood. OBJECTIVE To study the(More)
BACKGROUND AND PURPOSE Given the complex nature of chronic pain, the effects of high-intensity aerobic exercise on pain, disability, psychological strain, and serum cortisol concentrations in people(More)
CONTEXT The myokine irisin may increase energy expenditure and affect metabolism. OBJECTIVE The objective of the study was to elucidate predictors of irisin and study whether circulating irisin may(More)