Vassilis D Samaras

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OBJECTIVE Atypical teratoid/rhabdoid tumors are aggressive neoplasms of the central nervous system occurring mainly in the early childhood and rarely in adults. We described a case of this tumor in an 18-year-old male patient without previous medical history. MATERIAL AND METHODS The neoplasm was localized in the right frontotemporal area of the brain and(More)
BACKGROUND Sox11 is a transcription factor expressed in foetal and neoplastic brain tissue, including gliomas. It has been shown to suppress the tumourigenicity of glioma stem cells in vivo, thereby being hypothesised to function as a tumour suppressor. METHODS We investigated the expression of Sox11 in 132 diffuse astrocytomas in relation to the(More)
BACKGROUND Clear cell renal cell carcinomas (ccRCCs) constitute the most common renal carcinomas, characterized by a relatively aggressive clinical course. Thus, scientific research is targeting towards the identification of immunohistochemical and molecular markers that could be useful regarding diagnosis, appropriate therapy and prediction of prognosis.(More)
BACKGROUND Well differentiated neuroendocrine tumours (carcinoids), arising from cells of the diffuse neuroendocrine system, represent the most commonly encountered gastric endocrine tumours. Gastrointestinal stromal tumours (GISTs), which stem from interstitial Cajal cells located within the wall of the gastrointestinal tract and have a characteristic(More)
Although epigenetic alterations play an essential role in gliomagenesis, the relevance of aberrant histone modifications and the respective enzymes has not been clarified. Experimental data implicates histone H3 lysine (K) methyltransferases SETDB1 and SUV39H1 into glioma pathobiology, whereas linker histone variant H1.0 and H4K20me3 reportedly affect(More)
PURPOSE We present the unusual occurrence of two distinct neoplasms in a 42-year-old woman with an operated pituitary adenoma 18 years ago. METHODS Clinical history, magnetic resonance imaging studies and histopathological findings were utilized for our diagnostic considerations. RESULTS Concomitant presence of a cerebellar medulloblastoma secondary(More)
OBJECTIVES This study is an attempt to determine, the in vivo action of leptin on this hypophysiotropic hypothalamic area, by evaluating the concentrations of luteinizing hormone (LH) and follicular stimulating hormone (FSH) in the serum. METHODS The experiments were done by stereotaxic injection of recombinant rat leptin (rrleptin) into the third(More)
Gamma-angioscintigraphy of the cerebral vessels starting from the aortic arch localises better the level of an eventual vascular lesion preventing a "false positive" aspect, possible by the usual technique as in the case reported. By starting the examination at the level of the aortic arch or by the use of a diverging collimator it is easy to decide of the(More)
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