Vasiliy A. Zolotarev

Learn More
The G-protein-coupled sweet taste receptor dimer T1R2/T1R3 is expressed in taste bud cells in the oral cavity. In recent years, its involvement in membrane glucose sensing was discovered in endocrine cells regulating glucose homeostasis. We investigated importance of extraorally expressed T1R3 taste receptor protein in age-dependent control of blood glucose(More)
The heterodimeric protein T1R2/T1R3 is a chemoreceptor mediating taste perception of sugars, several amino acids, and non-caloric sweeteners in humans and many other vertebrate species. The T1R2 and T1R3 proteins are expressed not only in the oral cavity, but also in the intestine, pancreas, liver, adipose tissue, and in structures of the central nervous(More)
Proton pump inhibitors were shown to affect the sensitivity of the gastric mucosa to chemical agents. This effect is associated with inhibition of proton back-diffusion and increase in the permeability of the gastric epithelium. We studied the effect of omeprazole on gastric secretion of bicarbonates and pepsinogen induced by irritation of the gastric(More)
Acute experiments on anesthetized rats showed that group B nerve fibers of the subphrenic portion of the vagus nerve do not participate in the regulation of gastric secretion. Gastric acid production is mainly controlled by fast C-fibers (2.11 0.09 m/sec), while secretion of pepsinogen and bicarbonates depends on activity of both fast and slow (0.95 0.11(More)
The unit activity recorded in the right atrium plexus of the Langendorff preparation was spontaneously irregular in 20 per cent of the neurons. Hexamethonium abolishes it. The spontaneous activity and vagus-induced discharges were inhibited by adrenaline or by stimulation of the stellate ganglion in nearly 30 per cent of the neurons. Activity of some(More)
Effects of microelectrophoretic injections of picrotoxin on the neuronal receptive fields were studied in the vibrissae projection zone of S1 area in the cerebral cortex of anaesthetized cats. The sensitivity of neurons to the direction of vibrissae bending was completely abolished after picrotoxin influence. These facts show a great importance of(More)
  • 1