Vasilij Lebedev

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Transplantation of mesenchymal stem cells (MSCs), at early and later stages after local exposure of rats to 140 Gy 90Sr/90Y beta radiation, was found to stimulate recovery of damaged skin. The area of local radiation injuries (LRIs) and accelerated healing of radiation ulcers was obtained. Clinical evolution showed the high efficiency of the(More)
The effect of diethylstilbestrol on the hematopoietic system of intact animals and on dynamics of post-radiation hematopoiesis recovery was studied. The injection of diethylstilbestrol into unirradiated animals was shown to induce the decrease in CFUs and CFU-GM content in bone marrow, the increase in granulocyte-macrophage precursors number in spleen, the(More)
Emotional stress after radiation may aggravate the course of radiation-induced diseases. The use of the selective anxiolytic aphobazol (a drug from a mercaptobenzamidasol group) corrects development of adaptive reactions to stress in the blood system and normalizes its compensatory potentialities in animals under conditions of combined influence of(More)
The emotional stress after an irradiation can complicate the current of radiative defeats. At an emotional stress developing in early terms after an irradiation in low doses, are reduced adaptive and compensator capabilities of hemopoietic system. The emotional stress after a lethal dose irradiation inhibits the post-radiation recovery of haemopoiesis,(More)
In experiments on rats, disturbances in the development of blood system adaptive reactions on emotional stress were found. Under the combined effect of preliminary (before stress) exposure to 0.8 Gy of gamma-radiation and the emotional stress of various duration (2, 4 and 8 days), a compensatory capability of the blood system decreased. The degree of the(More)
The stimulatory effect of the preliminary whole body hyperthermia (WBH) on postradiation recovery of number both early hemopoietic progenitor cells (CFU-S and CFU-GM) and morphologically identifiable neutrophilic and erythroid cells in bone marrow was demonstrated in mice. Animals were exposed to the WBH (40 degrees C for 1 h.) 20 h before the irradiation(More)
In studying the influence of thymocytes fractionated by their size in the ficoll density gradient on the CFUs content of the irradiated mouse bone marrow, two subpopulations of T-cells were isolated: the administration of the first thymocyte subpopulation decreased the CFUs content during the postirradiation recovery period while thymocytes of the second(More)