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  • Tamara J. Nicolson, Elisa A. Bellomo, +30 authors Guy A. Rutter
  • Biology, Medicine
  • Diabetes
  • 2009 (First Published: 1 September 2009)
  • OBJECTIVE Zinc ions are essential for the formation of hexameric insulin and hormone crystallization. A nonsynonymous single nucleotide polymorphism rs13266634 in the SLC30A8 gene, encoding theContinue Reading
  • Christine A. Robson-Doucette, Sobia Sultan, +7 authors Michael B Wheeler
  • Medicine, Biology
  • Diabetes
  • 2011 (First Published: 1 November 2011)
  • OBJECTIVE The role of uncoupling protein 2 (UCP2) in pancreatic β-cells is highly debated, partly because of the broad tissue distribution of UCP2 and thus limitations of whole-body UCP2 knockoutContinue Reading
  • Valery Diatchuk, Ofra Lotan, Vasilij Koshkin, Peter Wikstroem, Edgar Pick
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • 1997 (First Published: 16 May 1997)
  • The elicitation of an oxidative burst in phagocytes rests on the assembly of a multicomponental complex (NADPH oxidase) consisting of a membrane-associated flavocytochrome (cytochrome b559),Continue Reading
  • Hongfang Lu, Vasilij Koshkin, Emma M. Allister, Armen V. Gyulkhandanyan, Michael B Wheeler
  • Biology, Medicine
  • Diabetes
  • 2010 (First Published: 1 February 2010)
  • OBJECTIVE The inability of pancreatic beta-cells to appropriately respond to glucose and secrete insulin are primary defects associated with beta-cell failure in type 2 diabetes. MitochondrialContinue Reading
  • Gladwin Joseph, Yara Gorzalczany, Vasilij Koshkin, Edgar Pick
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • 1994 (First Published: 18 November 1994)
  • The small GTP-binding protein (G protein) Rac1 is an obligatory participant in the assembly of the superoxide (O2-.)-generating NADPH oxidase complex of macrophages. We investigated the effect ofContinue Reading