Vasco A. Oliveira

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The PAAD 1 domain is found in diverse proteins implicated in apoptosis, inflammation, and cancer (1). This protein fold, which is also known as PYRIN or DAPIN (2– 4), is predicted to form an ␣-helical bundle resembling death domains, death effector domains, and Caspase activation and recruitment domains (CARDs). The PAAD domain thus constitutes the fourth(More)
Hypoxia-inducible factor-1 (HIF-1) plays a central role in tumor progression by regulating genes involved in proliferation, glycolysis, angiogenesis, and metastasis. To improve our understanding of HIF-1 regulation by kinome, we screened a kinase-specific small interference RNA library using a hypoxia-response element (HRE) luciferase reporter assay under(More)
BACKGROUND This cooperative group adjuvant phase 2 trial in patients with completely resected stage I non-small cell lung cancer with tumor diameters measuring ≥ 2 cm was designed to assess the feasibility and preliminary efficacy of assigning patients to therapy or observation using a molecularly based decision algorithm. METHODS At least a lobectomy and(More)
Cathepsin B is a lysosomal thiolprotease that, because of its colocalization with renin and its ability to activate prorenin, has been proposed as a prorenin processing enzyme. To characterize the biochemical aspect of this potential cathepsin B activity in more detail, we synthesized and assayed with human cathepsin B the internally quenched fluorescent(More)
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