Vas P. Demas

Learn More
Genes Kcna1 and Kcna2 code for the voltage-dependent potassium channel subunits Kv1.1 and Kv1.2, which are coexpressed in large axons and commonly present within the same tetramers. Both contribute to the low-voltage-activated potassium current I Kv1, which powerfully limits excitability and facilitates temporally precise transmission of information, e.g.,(More)
The opisthotonos (opt) mutation arose spontaneously in a C57BL/Ks-db2J colony and is the only known, naturally occurring allele of opt. This mutant mouse was first identified based on its ataxic and convulsive phenotype. Genetic and molecular data presented here demonstrate that the type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) protein, which serves(More)
The functional diversity of voltage-gated K+ channels may be partially determined by the mechanisms that permit or limit the assembly of molecularly diverse K+ channel subunits. To determine possible amino acid sequence domains required for subunit assembly and expression, we have constructed 15 N- and C-terminal interstitial or truncation deletion(More)
Genes Kcna1 and Kcna2 code for the voltage-dependent potassium channel subunits Kv1.1 and Kv1.2 which are co-expressed in large axons and commonly present within the same tetramers. Both contribute to the lowvoltage-activated potassium current IKv1 which powerfully limits excitability and facilitates temporally precise transmission of information, e.g. in(More)
  • 1