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Podophyllum hexandrum Royle is known for its vast medicinal properties, particularly anticancer. It contains higher amount of podophyllotoxin (4.3 %), compared to Podophyllum peltatum (0.025 %) and other plant species; as a result, it has been used worldwide in the preparation of various drugs including anticancer, antimalarial, antiviral, antioxidant,(More)
The present study was designed to evaluate the effect of palmatine on memory of Swiss young male albino mice. Palmatine (0.1, 0.5, 1 mg/kg, i.p.) and physostigmine (0.1 mg/kg, i.p.) per se were administered for 10 successive days to separate groups of mice. Effect of drugs on learning and memory of mice was evaluated using elevated plus maze and Morris(More)
— Few years ago, the information flow in education field was relatively simple and the application of technology was limited. However, as we progress into a more integrated world where technology has become an integral part of the business processes, the process of transfer of information has become more complicated. Today, one of the biggest challenges(More)
Higher education, throughout the world is delivered through universities, colleges affiliated to various universities and some other recognized academic institutes. Today one of the biggest challenges, the educational institutions face, is the explosive growth of educational data and to use this data to improve the quality of managerial decisions to deliver(More)
Picrosides, the terpenoids synthesized by Picrorhiza kurroa, have ample usage in medicine. Identification of the regulatory enzymes involved in picroside biosynthesis needs to be explored for improving the level of these secondary metabolites. Current efforts are based on the analysis of secondary metabolism in picroside biosynthesis but its interpretation(More)
siRNA therapeutics have promise for the treatment of a wide range of genetic disorders. Motivated by lipoproteins, we report lipopeptide nanoparticles as potent and selective siRNA carriers with a wide therapeutic index. Lead material cKK-E12 showed potent silencing effects in mice (ED50 ∼ 0.002 mg/kg), rats (ED50 < 0.01 mg/kg), and nonhuman primates (over(More)
Background. It is highly cost effective to detect a seasonal trend in tuberculosis in order to optimize disease control and intervention. Although seasonal variation of tuberculosis has been reported from different parts of the world, no definite and consistent pattern has been observed. Therefore, the study was designed to find the seasonal variation of(More)
This paper reports the optimum conditions for the extraction of picrosides from Picrorhiza kurroa using response surface methodology (RSM). A central composite design (CCD) was used to investigate the effects of four independent variables, namely methanol concentration (%), solid-to-liquid ratio (g/mL), incubation time (min) and temperature (°C) on the(More)